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Identification of the insertions, deletions and point mutations in rhomboid proteases from selected Mycobacterium species
(Makerere University, 2014-11)
Background: Rhomboids, proteins that are conserved in all life kingdoms, are among the novel genes likely to encode roles in the pathogenesis of mycobacteria. While rhomboids have various specific functions across species, ...
Prevalence and factors associated with depressive illness in patients with tuberculosis in Mulago Hospital
Background: Depression is a major cause of the global disease burden and globally affects 350-400 million persons making it the largest contributor to years lived with disability. Among patients with chronic physical ...
Prevalence and factors associated with pulmonary tuberculosis among children aged 2 to 59 months presenting with severe pneumonia at Alsabah Children’s Hospital, Juba, South Sudan
(Makerere University, 2019-09)
Background: Tuberculosis (TB) is a major public health problem at a global level. According to the World Health Organization (WHO) in 2018, approximately 10 million people developed TB in 2017, of which 1.0 million (10%) ...
Strain diversity of mycobacterium tuberculosis non-Uganda isolates from patients with pulmonary tuberculosis in Kawempe
(Makerere University, 2013-05)
Background: Tuberculosis is a major public health problem in peri-urban areas of Kampala and Uganda in general. To date there is inconclusive information about strain diversity of Mycobacterium tuberculosis of the non ...
Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)
Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ...
Uptake of urine lipoarabinomannan and associated factors in diagnosis of tuberculosis among patients with advanced HIV disease in selected Kampala Capital City Authority HIV clinics
(Makerere University, 2022-12)
Background: Despite tuberculosis (TB) being the leading cause of death and hospitalization among people living with HIV (PLHIV), its diagnosis among this patient population remains a challenge leading to missed opportunities ...
Effect of COVID-19 period on tuberculosis treatment success; A mixed methods study among tuberculosis patients at Jinja Regional Referral Hospital
(Makerere University, 2022-01)
Introduction: Before the COVID-19 pandemic, over 4000 people were dying from TB every day. TB is still a major public health threat globally, but the TB epidemic may be exacerbated by the COVID-19 pandemic. The lockdown ...
Patients' satisfaction with tuberculosis services provided at selected health facilities in Mityana District, Uganda
(Makerere University, 2022-08)
Introduction
The quality of Tuberculosis health care is critical for improved treatment outcomes. Patient satisfaction surveys are important indicators of the quality of services offered however, there is limited information ...
Developing a theory informed intervention to improve linkage to treatment for patients diagnosed with tuberculosis using XPERT® MTB/RIF testing in Central and Eastern Uganda
(Makerere University, 2022-11)
Background:
In 2019, Uganda notified only 74% of estimated TB cases against an END TB target of 90%. This
gap between estimated incident TB cases and those accessing TB treatment is due to a combination
of underdiagnosis ...
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)
Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ...