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Sputum microRNA profiles of treatment-naïve and patients on antituberculosis therapy in Mulago National Referral Hospital
(Makerere University, 2021-03-29)
Background: Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious
agent. This is attributed to the limitations of the current diagnostic tests in terms of sensitivity and
specificity. ...
Case detection of tuberculosis patients using machine learning : a case study of China Friendship Hospital Naguru, Kampala
(Makerere University, 2021-08-18)
Although early detection and treatment of Tuberculosis cases are the hallmark of successful TB control, diagnostic delay is still long and common in Uganda. Therefore, the study aimed at developing a tool that uses ...
Facilitators and barriers to tuberculosis case notification among private health facilities in Kampala Capital City
(Makerere University, 2022-08)
Introduction: The linkage of Private Health Providers (PHPs) is known to improve Tuberculosis (TB) case finding in the fight against the TB epidemic. In Uganda, 58% of people with TB related symptoms seek care initially ...
Practices of diagnosis and treatment of pulmonary tuberculosis, associated factors, barriers and facilitators among private practitioners in Kampala, Uganda
(Makerere University, 2020-11)
Introduction: Globally, tuberculosis (TB) is a leading cause of morbidity and mortality accounting for an estimated 10.0 million new cases and 1.451million deaths in 2018. Uganda is one of the world’s high TB burden countries ...
Test and treat policy: Effect on ART initiation and retention and health system barriers and facilitators to implementation in AHF Uganda Cares Clinics in Central Uganda
(Makerere University, 2022-05)
Background: The ‘Test and Treat’ policy was introduced by the WHO in 2015 as a measure to extend the benefits of ART to all HIV positive patients and, in a bid to enable the achievement of the UNAIDS 95-95-95 2030 ...
Prevalence, immunological profile, and factors associated with latent tuberculosis infection among adults with diabetes mellitus at Kiruddu National Referral Hospital
(Makerere University, 2022-10)
Introduction: The dual epidemic of Diabetes Mellitus (DM) and tuberculosis (TB) is a growing public health challenge in Sub-Saharan Africa (SSA), Uganda inclusive. Due to the immunologic dysfunction associated with diabetes ...
Utility of urine LAM Biomarker for treatment response monitoring during 8 weeks of MDR-TB treatment at Mulago National Referral Hospital
(Makerere University, 2022-03)
Background: The current methods used in monitoring treatment response among MDR - TB patients have low sensitivity, take long to give results, are expensive and require BSL3 facilities. It is known that MTB LAM as a biomarker ...
Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)
Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ...
Uptake of urine lipoarabinomannan and associated factors in diagnosis of tuberculosis among patients with advanced HIV disease in selected Kampala Capital City Authority HIV clinics
(Makerere University, 2022-12)
Background: Despite tuberculosis (TB) being the leading cause of death and hospitalization among people living with HIV (PLHIV), its diagnosis among this patient population remains a challenge leading to missed opportunities ...
Effect of COVID-19 period on tuberculosis treatment success; A mixed methods study among tuberculosis patients at Jinja Regional Referral Hospital
(Makerere University, 2022-01)
Introduction: Before the COVID-19 pandemic, over 4000 people were dying from TB every day. TB is still a major public health threat globally, but the TB epidemic may be exacerbated by the COVID-19 pandemic. The lockdown ...