Browsing Infectious Diseases Institute (IDI) Collections by Author "Kambugu, Andrew"
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Are the best antiretrovirals being used in Africa?
John, Laurence; Kambugu, Andrew; Songa, Patricia; castelnouvo, Barbara; Colebunders, Robert; Kamya, Moses (Mediscript Limited, 2006)No Abstract -
Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda
Wanyama, Jane; Castelnuovo, Barbara; Wandera, Bonnie; Mwebaze, Patricia; Kambugu, Andrew; Bangsberg, David R.; Kamya, Moses R. (Lippincott Williams & Wilkins., 2007)Although recent data suggest high levels of adherence to expanding antiretroviral therapy (ART) programmes in resource-limited settings, the culture- specific barriers to adherence are poorly understood. In a prospective ... -
Cause-Specific Mortality and the Contribution of Immune Reconstitution Inflammatory Syndrome in the First 3 Years after Antiretroviral Therapy Initiation in an Urban African Cohort
Castelnuovo, Barbara; Manabe, Yukari C; Kiragga, Agnes; Kamya, Moses; Easterbrook, Philippa; Kambugu, Andrew (Infectious Diseases Society of America, 2009)Background. Although many studies have reported high early mortality among patients enrolled in antiretroviral therapy (ART) programs in sub-Saharan Africa—particularly among those individuals with advanced immunodeficiency— ... -
Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: A prospective cohort study
Boulware, David R.; Meya, David B.; Bergemann, Tracy L.; Wiesner, Darin L.; Rhein, Joshua; Musubire, Paul; Lee, Sarah J.; Kambugu, Andrew; Janoff, Edward N.; Bohjanen, Paul R. (PLoS Medicine, 2010)Background: Although antiretroviral therapy (ART) improves survival in persons with cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution inflammatory syndrome (IRIS), an exaggerated and ... -
Clinical presentation and aetiologies of acute or complicated headache among HIV-seropositive patients in a Ugandan clinic
Katwere, Michael; Kambugu, Andrew; Piloya, Theresa; Wong, Matthew; Hendel-Paterson, Brett; Sande, Merle A.; Ronald, Allan; Katabira, Elly; Were, Edward M.; Menten, Joris; Colebunders, Robert (BioMed Central, 2009)Background: We set out to define the relative prevalence and common presentations of the various aetiologies of headache within an ambulant HIV-seropositive adult population in Kampala, Uganda. Methods: We conducted a ... -
Cost Effectiveness of a Pharmacy-Only Refill Program in a Large Urban HIV/AIDS Clinic in Uganda
Babigumira, Joseph B; Castelnuovo, Barbara; Stergachis, Andy; Kiragga, Agnes; Shaefer, Petra; Lamorde, Mohammed; Kambugu, Andrew; Muwanga, Alice; Garrison, Louis P. (Public Library of Science, 2011-03-28)Background: HIV/AIDS clinics in Uganda and other low-income countries face increasing numbers of patients and workforce shortages. We performed a cost-effectiveness analysis comparing a Pharmacy-only Refill Program (PRP), ... -
Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial
Paton, Nichilas I.; Musaazi, Joseph; Kityo, Cissy; Walimbwa, Stephen; Hoppe, Anne; Balyegisawa, Apolo; Asienzo, Jesca; Kaimal, Arvind; Mirembe, Grace; Lugemwa, Abbas; Ategeka, Gilbert; Borok, Margaret; Mugerwa, Henry; Siika, Abraham; Odongpiny, Eva Laker A.; Castelnuovo, Barbara; Kiragga, Agnes; Kambugu, Andrew (Elsevier, 2022-04-20)Background WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed to ... -
The epidemiology and clinical correlates of HIV-1 co-receptor tropism in non-subtype B infections from India, Uganda and South Africa
Ataher, Quazi; Portsmouth, Simon; Napolitano, Laura, A.; Eng, Sybil; Greenacre, Anna; Kambugu, Andrew; Wood, Robin; Badal-Faesen, Sharlaa; Tressler, Randy (Journal of the International AIDS Society, 2012-01-26)Background: The introduction of C-C chemokine receptor type-5 (CCR5) antagonists as antiretroviral therapy has led to the need to study HIV co-receptor tropism in different HIV-1 subtypes and geographical locations. This ... -
Feasibility of virtual reality based training for optimising COVID-19 case handling in Uganda
Buyego, Paul; Katwesigye, Elizabeth; Kebirungi, Grace; Nsubuga, Mike; Nakyejwe, Shirley; Cruz, Phillip; McCarthy, Meghan C.; Hurt, Darrell; Kambugu, Andrew; Arinaitwe, Joseph Walter; Ssekabira, Umaru; Jjingo, Daudi (BMC Medical Education, 2022)Background: Epidemics and pandemics are causing high morbidity and mortality on a still-evolving scale exemplifed by the COVID-19 pandemic. Infection prevention and control (IPC) training for frontline health workers is ... -
Immune reconstitution disease of the central nervous system
Toroka, M. Estee; Kambugu, Andrew; Wright, Edwina (Lippincott Williams & Wilkins, 2008)Purpose of review The purpose of this review is to examine the literature concerning immune reconstitution disease associated with the central nervous system infections. Recent findings Immune reconstitution disease ... -
Measuring the outcomes of a comprehensive HIV care course: pilot test at the Infectious Diseases Institute, Kampala, Uganda
Weaver, Marcia R; Nakitto, Cecilia; Schneider, Gisela; Kamya, Moses R.; Kambugu, Andrew; Lukwago, Robinah; Ronald, Allan; McAdam, Keith; Sande, Merle A. (Lippincott Williams & Wilkins, 2006)Objective: To evaluate the effects of the Infectious Diseases Institute’s 4-week course for African doctors on comprehensive management of HIV including antiretroviral therapy on four outcomes: (1) clinical skills, (2) ... -
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
Kambugu, Andrew; Meya, David B.; Rhein, Joshua; O’Brien, Meagan; Janoff, Edward N.; Ronald, Allan R.; Kamya, Moses R.; Mayanja-Kizza, Harriet; Sande, Merle A.; Bohjanen, Paul R.; Boulware, David R. (CID, 2008)Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ... -
Potential impact of task-shifting on costs of antiretroviral therapy and physician supply in Uganda
Babigumira, Joseph B; Castelnuovo, Barbara; Lamorde, Mohammed; Kambugu, Andrew; Stergachis, Andy; Easterbrook, Philippa; Garisson, Louis P. (BMC Health Services Research, 2009-01-09)Background Lower-income countries face severe health worker shortages. Recent evidence suggests that this problem can be mitigated by task-shifting—delegation of aspects of health care to less specialized health workers. ... -
A Randomized controlled trial to evaluate the effectiveness of a board game on patients' knowledge uptake of HIV and sexually transmitted diseases at the Infectious Diseases Institute, Kampala, Uganda
Wanyama, Jane N; Castelnuovo, Barbara; Robertson, Gavin; Newell, Kevin; Sempa, Joseph B; Kambugu, Andrew; Manabe, Yuka C.; Colebunders, Robert (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2012-03-01)Background: As the number of HIV infections continues to rise, the search for effective health education strategies must intensify. A new educational board game was developed to increase HIV peoples' attention and knowledge ... -
Severe Renal Dysfunction and Risk Factors Associated with Renal Impairment in HIV-Infected Adults in Africa Initiating Antiretroviral Therapy
Reid, Andrew; Stohr, Wolfgang; Walker, Sarah A; Williams, Ian G.; Kityo, Cissy; Hughes, Peter; Kambugu, Andrew; Gilks, Charles F.; Mugyenyi, Peter; Munderi, Paula; Hakim, James; Gibb, Diana M. (CID, 2008)Background. We sought to investigate renal function in previously untreated symptomatic human immunodeficiency virus (HIV)–infected adults with CD4+ cell counts of !200 cells/mm3 who were undergoing antiretroviral therapy ... -
Sub-optimal vitamin B-12 levels among ART-Naïve HIV positive individuals in an urban cohort in Uganda
Semeere, Aggrey S.; Nakanjako, Damalie; Ddungu, Henry; Kambugu, Andrew; Manabe, Yukari C.; Colebunders, Robert (Public Library of Science, 2012-07-02)Malnutrition is common among HIV-infected individuals and is often accompanied by low serum levels of micronutrients. Vitamin B-12 deficiency has been associated with various factors including faster HIV disease progression ... -
Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a Resource-Limited Setting (Uganda).
Songa, Patricia Mwebaze; Castelnuovo, Barbara; Mugasha, Estella Birabwa; Ocama, Ponsiano; Kambugu, Andrew (University of Chicago Press, 2007)We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that ... -
Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a Resource-Limited Setting (Uganda).
Songa, Patricia Mwebaze; Castelnuovo, Barbara; Mugasha, Estella Birabwa; Ocama, Ponsiano; Kambugu, Andrew (University of Chicago Press, 2007-08-15)We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that ... -
A training for health care workers to integrate hepatitis B care and treatment into routine HIV care in a high HBV burden, poorly resourced region of Uganda: the ‘2for1’ project.
Nankya‑Mutyoba, Joan; Ejalu, David; Wandera, Claude; Beyagira, Rachel; Amandu, Jacinto; Seremba, Emmanuel; Mugagga, Kaggwa; Kambugu, Andrew; Muganzi, Alex; Easterbrook, Philippa; Ocama, Ponsiano (BMC Medical Education, 2022)Introduction: The “2for1” project is a demonstration project to examine the feasibility and effectiveness of HBV care integrated into an HIV clinic and service. An initial phase in implementation of this project was the ... -
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
Colebunders, Robert; John, L.; Huyst, V.; Kambugu, Andrew; Scano, F.; Lynen, L. (International Union Against Tuberculosis and Lung Disease, 2006)Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV ...