Browsing Infectious Diseases Institute (IDI) Collections by Type
Now showing items 1-20 of 54
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Adolescent pregnancy at antiretroviral therapy (ART) initiation: a critical barrier to retention on ART
(Wiley Online Library, 2018)Introduction: Adolescence and pregnancy are potential risk factors for loss to follow-up (LTFU) while on antiretroviral therapy (ART). We compared adolescent and adult LTFU after ART initiation to quantify the impact of ... -
Assessment of parasite clearance following treatment of severe malaria with intravenous artesunate in Ugandan children enrolled in a randomized controlled clinical trial
(BMC, 2018)Background Malaria control largely depends on availability of highly efficacious drugs, however, over the years, has been threatened by emergence of drug resistance. It is, therefore, important to monitor the impact of ... -
Barriers and facilitators to chemotherapy initiation and adherence for patients with HIV-associated Kaposi’s sarcoma in Kenya: A qualitative study
(BMC, 2022)Background: Kaposi sarcoma is one of the most prevalent HIV‑associated malignancies in sub‑Saharan Africa and is often diagnosed at advanced stage of disease. Only 50% of KS patients who qualify for chemotherapy receive ... -
Career development for infection and immunity research in Uganda: a decade of experience from the Makerere University - Uganda Virus Research Institute research and training programme
(African Academy of Science, 2020)Background: The Makerere University/Uganda Virus Research Institute (UVRI) Centre of Excellence for Infection & Immunity Research and Training (MUII) is a collaborative programme supporting excellence in Infection and ... -
Castelnuovo, B. et al. (2018). Antiretroviral treatment Long-Term (ALT) cohort: a prospective cohort of 10 years of ART-experienced patients in Uganda
(BMJ, 2018)Purpose Little information is available on patients on antiretroviral treatment (ART) after a long-term period from sub-Saharan Africa, with the longest follow-up and related outcomes being after 10 years on ART. At the ... -
Cellular immune activation in cerebrospinal fluid from Ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome
(Oxford University Press, 2015)Background. Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM) is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid (CSF). The immunopathogenesis of CMimmune ... -
Characteristics and outcomes of admitted patients infected with SARS-CoV-2 in Uganda
(BMJ, 2020)Rationale: Detailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited. Objective: We determined the clinical characteristics and treatment outcomes of patients diagnosed ... -
Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda
(BMC, 2024)Introduction Young people living with HIV (YPLHIV) are at increased risk of developing chronic kidney disease (CKD) which is associated with high mortality and morbidity. Early diagnosis is important to halt progression. ... -
Contrasting impact of rural, versus urban, living on glucose metabolism and blood pressure in Uganda
(Wellcome Open research, 2020)Background: The burden of cardiometabolic diseases, including cardiovascular diseases and diabetes, is increasing in sub-Saharan Africa and this has been linked to urbanisation. Helminths, through their immunomodulatory ... -
Correlation between co-therapy of efavirenz-based ART and pregnancy among HIV-positive women on hormonal contraceptive implants at TASO Tororo-Uganda: A retrospective review
(2018)Background: We examined the association between EFV and non-EFV based ART regimens and pregnancy outcomes among women who were on HCI in a peri-urban HIV clinic in Tororo, Uganda. Methods: We reviewed and extracted routinely ... -
Cryptococcal disease in the era of “test and treat”: Is there cause for concern?
(Oxford University Press, 2017)Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution ... -
Delayed sputum culture conversion in tuberculosis human immunodeficiency virus–coinfected patients with low isoniazid and rifampicin concentrations
(Oxford Academic, 2018)Background. The relationship between concentrations of antituberculosis drugs, sputum culture conversion, and treatment outcome remains unclear. We sought to determine the association between antituberculosis drug ... -
Depressive and anxiety symptoms predict sustained quality of life deficits in HIV-positive Ugandan adults despite antiretroviral therapy
(Lippincott, 2016)The impact of psychosocial status at onset of antiretroviral therapy on changes in quality of life (QOL) and subjectively rated health (SRH) among adults on ART in resource-limited settings is poorly understood. Therefore, ... -
Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
(BioMed Central, 2018)HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although ... -
Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial
(Elsevier, 2022-04-20)Background WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed to ... -
Estimation of mortality among HIV-infected people on antiretroviral therapy treatment in East Africa: a sampling based approach in an observational, multisite, cohort study
(Elsevier, 2015)Background—Mortality after initiation of antiretroviral treatment (ART) among HIV-infected patients in resource limited settings is a critical measure of the effectiveness and comparative effectiveness of the global public ... -
Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi Sarcoma in Kenya: A cost-effectiveness analysis
(Elsevier, 2022)Background The most effective treatment for advanced AIDS-associated Kaposi sarcoma is paclitaxel or pegylated liposomal doxorubicin (PLD); neither is routinely used in sub-Saharan Africa due to limited availability and ... -
Feasibility of conducting a pilot randomized control trial of a psycho-education intervention in patients with a first episode psychosis in Uganda—A study protocol
(PLoS ONE, 2022)Background. Psychotic disorders contribute to significant morbidity and mortality partly due to the chronicity of the illness and high relapse rates. Delivering psycho-education messages about disease etiology, their signs ... -
Feasibility of virtual reality based training for optimising COVID-19 case handling in Uganda
(BMC Medical Education, 2022)Background: Epidemics and pandemics are causing high morbidity and mortality on a still-evolving scale exemplifed by the COVID-19 pandemic. Infection prevention and control (IPC) training for frontline health workers is ... -
Gastrointestinal cryptococcoma – Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?
(Elsevier, 2015)The introduction of antiretroviral therapy (ART) may lead to unusual paradoxical and unmasking presentations of opportunistic infections. Intra-abdominal cryptococcosis is a rare manifestation of Cryptococcus. We present ...