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dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorMerry, Concepta
dc.contributor.authorColebunders, Bob
dc.contributor.authorVan Geertruyden, Jean-Pierre
dc.date.accessioned2012-05-28T09:13:05Z
dc.date.available2012-05-28T09:13:05Z
dc.date.issued2009
dc.identifier.citationByakika-Kibwika P., Lamorde, M., Mayanja-Kizza, H., Merry, C., Colebunders, B., Van Geertruyden, J.P. (2009). Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria. Therapeutics and Clinical Risk Management, 5en_US
dc.identifier.issn1176-6336
dc.identifier.urihttp://hdl.handle.net/10570/590
dc.description.abstractArtemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria. It offers the advantage of rapid clearance of parasites by artemether and the slower elimination of residual parasites by lumefantrine. The combination can be used in all populations except pregnant mothers in the first trimester where safety is still uncertain. There are still concerns about safety and pharmacokinetics of the drug combination in children, especially infants, pregnant mothers and drug interactions with mainly non-nucleoside reverse transcriptase inhibitors and protease inhibitors used for HIV therapy.en_US
dc.language.isoenen_US
dc.publisherDove Medical Pressen_US
dc.subjectArtemether–lumefantrineen_US
dc.subjectSafetyen_US
dc.subjectMalariaen_US
dc.subjectEffectivenessen_US
dc.subjectEfficacyen_US
dc.subjectAntimalarial therapyen_US
dc.subjectFalciparum malariaen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectCD4 countsen_US
dc.subjectHIV/AIDSen_US
dc.titleUpdate on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malariaen_US
dc.typeJournal article, peer revieweden_US


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