College of Health Sciences (CHS): Recent submissions
Now showing items 1-20 of 3328
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Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner
(PNAS, 2022)HLA class I (HLA-I) allotypes vary widely in their dependence on tapasin (TAPBP), an integral component of the peptide-loading complex, to present peptides on the cell surface. We identified two single-nucleotide polymorphisms ... -
Sticks and wheelchairs for elderly people in central Uganda: values of utility, provenance and presentation
(Cambridge University Press, 2022)While mobility-assistive devices ease movement and independence of persons with disabilities, their use may depend on their social and symbolic meaning. This article departs from our observation that elderly people in ... -
High viral suppression and low attrition in healthy HIV-infected patients initiated on ART with CD4 above 500 cells/μL in a program setting in Uganda
(African Health Sciences, 2020)Background: The World Health Organization recommends antiretroviral therapy (ART) for all HIV-infected patients at all CD4 counts. However, there are concerns that asymptomatic patients may have poorer viral suppression ... -
Prevalence, associated factors and in-hospital outcomes of gastrointestinal perforations at Bwera General Hospital, Kasese - Uganda: a retrospective cross-sectional study
(Makerere University, 2025)Introduction: Gastrointestinal perforations (GIPs) constitute surgical emergencies which necessitate prompt diagnosis and management that is significantly facilitated by the availability of adequate facilities and resources. ... -
Indications, early complications, and the associated factors following open surgical gastrostomy in patients admitted to Mulago National Referral Hospital
(Makerere University, 2025)Background: Feeding gastrostomy, whether performed surgically or via percutaneous endoscopic or radiological methods, is the preferred approach for long-term enteral feeding in patients who are unable to swallow but possess ... -
Accuracy of ganga hospital open injury score in predicting amputation of severe open lower limb injuries among adults seen at Mulago Hospital
(Makerere University, 2025)Background: With the recent advent of more motorization in Uganda, severe open lower limb injuries are pretty common. Hence, a frequent ethical and medical-legal dilemma in decision-making by frontline clinicians often ... -
Research priorities to inform “Treat All” policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA)
(Wiley Online Library, 2019)Introduction “Treat All” – the treatment of all people with HIV, irrespective of disease stage or CD4 cell count – represents a paradigm shift in HIV care that has the potential to end AIDS as a public health threat. With ... -
Prevalence and patterns of humeral fractures amongst patients presenting with upper limb fractures to Mulago National Referral Hospital.
(Makerere University, 2025)Introduction: Humeral fractures are some of the major orthopaedic injuries presenting to the Accident and Emergency unit among patients with musculoskeletal trauma. However, their true prevalence and patterns is not yet ... -
Diagnostic accuracy of the modified triple test in evaluation of palpable breast masses among women under 40 years attending Mulago Hospital
(Makerere University, 2025)Background: Breast lumps remain the commonest presentation among women at outpatient clinics in Uganda. However, the diagnostic utility of the modified triple test, MTT (physical breast examination, breast ultrasound, ... -
A qualitative exploratory interview study on birth companion support actions for women during childbirth
(BMC, 2022)Abstract Background: The World Health Organization recommends that women are supported continuously throughout labor by a companion of their choice. And, that companions have clearly designated roles and responsibilities ... -
Contraceptive acceptability and associated factors among young women (15-24) living with HIV/AIDS: a hospital-based study in Kampala, Uganda
(African Health Sciences, 2022)Introduction: In Uganda, over 43% of all pregnancies among young women (15-24 years) living with HIV are either unwanted or mistimed. Unintended pregnancies account for 21.3% of neonatal HIV infections. The objective was ... -
Pharmacokinetic and pharmacodynamic considerations of rifamycin antibiotics for the treatment of tuberculosis
(Taylor and Francis, 2019)Tuberculosis (TB) treatment was revolutionized in 1965 with the discovery of rifamycins by Sensi et al. [1]. With the introduction of rifamycins, treatment duration drastically decreased from 18 to 6 months [2]. Rifamycins, ... -
Evaluation of effective lactogenic doses of Moringa oleifera ethanol extract in Swiss Albino Rats
(Makerere University, 2022)Introduction Breastfeeding is a foundation of child development health and survival, women with insufficient milk use Moringa oleifera in enhancing breast milk without standard doses and dosage forms. Literature review. ... -
Factors associated with in-hospital mortality of neonates with anorectal malformations at Mulago National Referral Hospital
(Makerere University, 2025)Background Anorectal malformation is a common disease entity among neonates presenting to pediatric surgery units in Uganda. The optimal care for these babies is compromised by gaps in several of the pillars of the ... -
Predictive role of neurofilament light protein in neurological and mental health outcomes following non-severe trauma among adults: A prospective cohort study at Mulago National Referral Hospital
(Makerere University, 2025)INTRODUCTION- Traumatic Brain Injury (TBI) is a major risk for neurological and neuropsychological disorders. Neuroaxonal damage is a major determinant of outcomes of TBI, and Neurofilament Light chain protein (NfL), a ... -
Prevalence, etiology and computed tomography finding in patients with traumatic brain injury at Mulago National Referral Hospital: A cross sectional study
(Makerere University, 2025)Background: Traumatic brain injury (TBI) refers to brain damage following trauma to the head. It is one of the leading causes of morbidity and mortality in the world. The incidence of TBI is a growing burden due to increasing ... -
Prevalence of multi-drug resistant UTIs and antibiotic sensitivity profiles amongst male patients with bladder outlet obstruction: A cross-sectional study
(Makerere University, 2025)Background: Antimicrobial resistance (AMR) is a rapidly emerging global problem with multidrug resistant (MDR) urinary tract infections (UTIs) complicating treatment, particularly in low and middle-income countries (LMICs). ... -
Prosthetic fitting and associated factors among lower limb amputees at Mulago Hospital
(Makerere University, 2025)Background: Lower limb amputations are a significant global health challenge, with Uganda experiencing a notable burden. Despite the essential role of prosthetic fitting in rehabilitation, disparities in access and prosthetic ... -
Prevalence, correlates, and predictive value of high-risk human papillomavirus mRNA detection in a community-based cervical cancer screening program in Western Uganda
(BMC, 2019)Background: New strategies are needed to combat the high incidence of cervical cancer in resource-limited settings such as sub-Saharan Africa. Screening for high-risk human papillomavirus (hrHPV) DNA is sensitive for ... -
Longer-term effectiveness of protease-inhibitor-based second line antiretroviral therapy in four large sub-Saharan African clinics
(Elsevier, 2019)Objectives: Data on the longer-term effectiveness of second line combination antiretroviral therapy (ART) in sub-Saharan Africa (SSA) are lacking. We sought to assess the probability and determinants of 2nd line ART ...