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Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults
(Public Library of Science, 2008-12-19)
Background: Generic antiretroviral therapy is the mainstay of HIV treatment in resource-limited settings, yet there is little evidence confirming the bioequivalence of generic and brand name formulations. We compared the ...
Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?
(African Health Sciences, 2008-06)
Introduction: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this ...
Analysis of HIV-1 sub types among blood donors in Uganda using a multi-region hybridization assay.
(2008-04)
BACKGROUND:
Uganda has been a focus of HIV/AIDS intervention efforts, including vaccine clinical trials. HIV-1 genetic diversity poses challenges for design of efficacious vaccines. Data on HIV-1 genetic diversity is ...
The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda
(Makerere University Medical School, 2008-03)
Background: Liver diseases are common in patients with HIV due to viral hepatitis B and C co-infections, opportunistic infections or malignancies, antiretroviral drugs and drugs for opportunistic infections. Objective: To ...
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
(CID, 2008)
Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ...
Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance
(BioMed Central, 2008-10)
Background: A proportion of individuals who start antiretroviral therapy (ART) fail to achieve adequate CD4 cell reconstitution despite sustained viral suppression. We determined the frequency and clinical significance of ...
Survival of infants born to HIV-positive mothers, by feeding modality, in Rakai, Uganda
(Public Library of Science, 2008-12-09)
Background: Data comparing survival of formula-fed to breast-fed infants in programmatic settings are limited. We compared mortality and HIV-free of breast and formula-fed infants born to HIV-positive mothers in a program ...
The safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda.
(Public Library of Science, 2008-06)
Background
The objective of the study was to compare rates of adverse events (AEs) related to male
circumcision (MC) in HIV-positive and HIV-negative men in order to provide guidance for MC programs that may provide ...
Assessment of the drug storage facilities and quality of generic co-formulation tablets (Stavudine, Lamivudine, Nevirapine) at HIV/AIDS treatment centers in Uganda.
(Medwell Journals, 2008)
The study investigated the storage facilities and the quality of co-formulation tablets containing stavudine, lamivudine, and nevirapine at four treatment centres in Uganda. A cross-sectional survey of drug storage conditions ...
Differences in factors associated with initial growth, CD4, and viral load responses to ART in HIV-Infected children in Kampala, Uganda, and the United Kingdom/Ireland
(Lippincott Williams & Wilkins, 2008-12-01)
Background: Few studies have directly compared response to antiretroviral therapy (ART) between children living in wellresourced and resource-limited settings. In resource-limited settings non-HIV contributors could reduce ...