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Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults
(Public Library of Science, 2008-12-19)
Background: Generic antiretroviral therapy is the mainstay of HIV treatment in resource-limited settings, yet there is little evidence confirming the bioequivalence of generic and brand name formulations. We compared the ...
Voices on adherence to ART in Ethiopia and Uganda: a matter of choice or simply not an option
(Routledge - Taylor & Francis, 2009)
This paper explores HIV patients’ adherence to antiretroviral treatment (ART) in resource-limited contexts in Uganda and Ethiopia, where ART is provided free of charge. Qualitative semi-structured interviews were conducted ...
Potential impact of task-shifting on costs of antiretroviral therapy and physician supply in Uganda
(BMC Health Services Research, 2009-01-09)
Background Lower-income countries face severe health worker shortages. Recent evidence suggests that this problem can be mitigated by task-shifting—delegation of aspects of health care to less specialized health workers. ...
Antiretroviral therapy improves cognitive impairment in HIV individuals in Sub-Saharan Africa
(American Academy of Neurology (AAN), 2006)
Abstract—Background: Highly active antiretroviral therapy (HAART) can improve cognitive performance in some patients
with HIV-associated cognitive impairment in the United States. The effect of HAART on HIV dementia ...
The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda
(Makerere University Medical School, 2008-03)
Background: Liver diseases are common in patients with HIV due to viral hepatitis B and C co-infections, opportunistic infections or malignancies, antiretroviral drugs and drugs for opportunistic infections. Objective: To ...
Steady-state pharmacokinetic comparison of generic and branded formulations of stavudine, lamivudine and nevirapine in HIV-infected Ugandan adults
(Oxford University Press, 2008-07-19)
Background: We aimed to compare the steady-state pharmacokinetic parameters and tolerability of Triomune 40w (stavudine 40 mg, lamivudine 150 mg and nevirapine 200 mg) and branded formulations of these drugs in HIV-infected ...
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
(CID, 2008)
Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ...
Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a Resource-Limited Setting (Uganda).
(University of Chicago Press, 2007)
We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that ...
Longitudinal antiretroviral adherence in HIV+ Ugandan parents and their children initiating HAART in the MTCT-plus family treatment model: role of depression in declining adherence over time.
(Springer, 2009-03-20)
We conducted a study to assess the effect of family-based treatment on adherence amongst HIV-infected parents and their HIV-infected children attending the Mother-To-Child-Transmission Plus program in Kampala, Uganda. ...
Evaluation of Dynabeads and Cytospheres Compared With Flow Cytometry to Enumerate CD41 T Cells in HIV-Infected Ugandans on Antiretroviral Therapy
(Lippincott Williams & Wilkins., 2008-07-01)
Background: Laboratory-based monitoring of antiretroviral therapy is essential but adds a significant cost to HIV care. The World Health Organization 2006 guidelines support the use of CD4 lymphocyte count (CD4) to define ...