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Antimalarial drug levels in biological samples: methods and applications.
(2008-09)
This thesis deals with the development and validation of analytical methods that are field-adapted and their application in the determination of antimalarial drug levels in biological samples. These methods are suitable ...
Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
(BioMed Central, 2012-04-27)
Background: Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess ...
Variations of plasma concentrations of artemether-lumefantrine with age and weight in children presenting with uncomplicated malaria at Mulago Hospital.
(2009-10)
INTRODUCTION:
Malaria is still one of the main causes of mortality and morbidity in Ugandan children with the under 5 year mortality rate of 136/100,000. ACTs are the first line of treatment of uncomplicated malaria. ...
Malaria control methods used by the community in peri-urban area (Ndeeba Parish)
(1997)
Malaria threatens 2200 million people worldwide every year. The disease undermines the health and welfare of mainly women and children. Malaria is the leading cause of morbidity and mortality in Uganda. Close to 50% of the ...
Factors influencing coartem uptake of children 6 to 59 months old with umcomplicated malaria in Ntungamo District, Uganda.
(2009)
INTRODUCTION:
Artemisinin based combination therapies are recommended for malaria treatment. In Ntungamo district, only 38% of the children aged 6 to 59 months receive coartem following onset of fever compared to national ...
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
(University of Chicago Press, 2005-11-18)
Background. Human immunodeficiency virus (HIV) infection may increase the burden of malaria by increasing susceptibility to infection or by decreasing the response to antimalarial treatment. We investigated the seroprevalence ...
Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria
(The American Society of Tropical Medicine and Hygiene, 2009)
We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association ...
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
(Public Library of Science, 2008-06)
Background:
Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ...
Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria
(American Society of Tropical Medicine and Hygiene, 2009)
We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association ...
Health workers’ compliance to treatment guidelines for uncomplicated malaria under the artemether-lumefantrine drug policy in Hoima District.
(Makerere University, 2013-03)
Introduction: In June 2004, the Uganda Ministry of Health changed the antimalarial drug policy from chloroquine and fansidar to a fixed combination of artemether-lumefantrine. Consequently, new case management guidelines ...