Browsing College of Health Sciences (CHS) by Author "Worodria, William"
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The aetiology of pulmonary infections among AAFB sputum smear negative HIV adults presenting to Mulago hospital
Worodria, William (2000)Background: Pulmonary infections are an important cause of complications in up to 60% of HIV infected patients during the course of their disease. Tuberculosis (TB) is a common cause of such infections. Sub-Saharan Africa ... -
Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV infected patients
Cattamanchi, Adithya; Ssewenyana, Isaac; Nabatanzi, Rose; Den Boon, Saskia; Andama, Alfred; Worodria, William; Cao, Huyen; Huang, Laurence; Davis, J. Lucian; Miller, Cecily R. (Public Library of Science, 2012-06-26)Background: Peripheral blood interferon-gamma release assays (IGRAs) have sub-optimal sensitivity and specificity for diagnosis of active pulmonary tuberculosis (TB). However, assessment of local immune responses has been ... -
Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection
Worodria, William; Menten, Joris; Massinga-Loembe, Marguerite; Mazakpwe, Doreen; Bagenda, Danstan; Koole, Olivier; Mayanja-Kizza, Harriet; Kestens, Luc; Mugerwa, Roy; Reiss, Peter; Colebunders, Robert; The TB-IRIS study group (International Medical Press, 2012)BACKGROUND: Here, we aimed to determine the clinical spectrum, predictors and outcomes of paradoxical tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in a resource-limited setting. METHODS: In a ... -
Coping with TB immune reconstitution inflammatory syndrome
Worodria, William; Conesa-Botella, Anali; Kisembo, Harriet; McAdam, Keith P.W.J; Colebunders, Robert (Expert Reviews, 2009)The TB immune reconstitution inflammatory syndrome (IRIS) is a relatively frequent complication in HIV–TB-coinfected patients after they start highly active antiretroviral therapy (HAART). There are two forms of TB IRIS: ... -
In reply to `Empirical tuberculosis treatment or improved diagnostics?'
Manabe, Yukari C.; Worodria, William; Cobelens, Frank (International Union Against Tuberculosis and Lung Disease, 2012-02-16)We read the article by Lawn and colleagues with great interest. Atypical presentation and limited diagnostic capability in resource-limited settings lead to delays in treatment that could contribute to high rates of ... -
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy
Worodria, William; Massinga-Loembe, Marguerite; Mazakpwe, Doreen; Luzinda, Kenneth; Menten, Joris; Van Leth, Frank; Mayanja-Kizza, Harriet; Kestens, Luc; Mugerwa, Roy D.; Reiss, Peter; Colebunders, Robert (Lippincott Wilkins & Williams, 2011)Background: Tuberculosis-HIV (TB-HIV) coinfection remains an important cause of mortality in antiretroviral therapy (ART) programs. In a cohort of TB-HIV–coinfected patients starting ART, we examined the incidence and ... -
Low prevalence of pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia
Taylor, Steve, M.; Meshnick, Steven, R.; Worodria, William; Andama, Alfred; Davis, J. Lucian; Cattamanchi, Adithya; Den Boon, Saskia; Yoo, Samuel D.; Goodman, Carol D.; Huang, Laurence (SciVerse ScienceDirect, 2012-02-15)Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)–infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed ... -
Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV prevalence setting: a prospective cohort study
Davis, J. Lucian; Huang, Laurence; Worodria, William; Masur, Henry; Cattamanchi, Adithya; Huber, Charles; Miller, Cecily; Conville, Patricia S.; Murray, Patrick; Kovacs, Joseph A. (Public Library of Science, 2011-01)Background: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. ... -
The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country
Worodria, William; Anderson, Julian; Cattamanchi, Adithya; Davis, J. Lucian; Boon, Saskia Den; Andama, Alfred; Yoo, Samuel D.; Joloba, Moses; Huang, Laurence; Kato-Maeda, Midori (Public Library of Science, 2011-11)Objective: To determine the need for routine speciation of positive Lowenstein-Jensen mycobacterial cultures in HIVinfected patients suspected of having pulmonary tuberculosis at Mulago Hospital in Kampala, Uganda. Methods: ... -
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
Meintjes, Graeme; Lawn, Stephen D.; Scano, Fabio; Maartens, Gary; French, Martyn A.; Worodria, William; Elliott, Julian H.; Murdoch, David; Wilkinson, Robert J.; Seyler, Catherine; John, Laurence; van der Loeff, Maarten Schim; Reiss, Peter; Lynen, Lut; Janoff, Edward N.; Gilks, Charles; Colebunders, Robert (Elsevier, 2008-08)The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there ... -
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
Meintjes, Graeme; Lawn, Stephen D.; Scano, Fabio; Maartens, Gary; French, Martyn A.; Worodria, William; Elliott, Julian H.; Murdoch, David; Wilkinson, Robert J.; Seyler, Catherine; John, Laurence; Lynen, Lut; Janoff, Edward N.; Gilks, Charles; Colebunders, Robert; van der Loeff, Maarten Schim (Elsevier, 2008-08)The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there ...