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Now showing items 31-40 of 105
Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
(BioMed Central, 2012-04-27)
Background: Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess ...
A Randomized controlled trial to evaluate the effectiveness of a board game on patients' knowledge uptake of HIV and sexually transmitted diseases at the Infectious Diseases Institute, Kampala, Uganda
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2012-03-01)
Background: As the number of HIV infections continues to rise, the search for effective health education strategies must intensify. A new educational board game was developed to increase HIV peoples' attention and knowledge ...
Adherence to antiretroviral therapy in HIV-positive adolescents in Uganda assessed by multiple methods a prospective cohort study
(Adis, 2012-10)
Background: The effectiveness of traditional adherence measurements used in adolescent populations isdifficult to assess. Antiretroviral (ARV) adherence research among adolescents living with HIV in resourceconstrained ...
Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
(Oxford University Press, 2012)
Objectives: Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug–drug interactions between artemether/lumefantrine and efavirenz ...
Incremental yield of serial sputum cultures for diagnosis of tuberculosis among HIV infected smear negative pulmonary TB suspects in Kampala, Uganda
(PLoS ONE, 2012-05-22)
Background: Sputum culture is the gold standard for diagnosis of pulmonary tuberculosis (PTB). Although mostly used for research, culture is recommended by the World Health Organization for TB diagnosis among HIV infected ...
Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV infected patients
(Public Library of Science, 2012-06-26)
Background: Peripheral blood interferon-gamma release assays (IGRAs) have sub-optimal sensitivity and specificity for diagnosis of active pulmonary tuberculosis (TB). However, assessment of local immune responses has been ...
Pharmacokinetics of antiretroviral drug varies with formulation in the target population of children with HIV-1
(Clinical Pharmacology & Therapeutics (Nature Publishing Group), 2012-02-21)
The bioequivalence of formulations is usually evaluated in healthy adult volunteers. In our study in 19 HIV-1-infected Ugandan children (1.8–4 years of age, weight 12 to <15 kg) receiving zidovudine, lamivudine, and abacavir ...
Impact of antiretroviral therapy on the incidence of Kaposi’s sarcoma in resource-rich and resource-limited settings
(Lippincott, Williams & Wilkins, 2012)
Purpose of review
Given the recent availability of antiretroviral therapy (ART) in resource-limited settings and the significant burden exacted by Kaposi’s sarcoma in these areas, we reviewed data regarding the impact of ...
Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: A prospective cohort study
(PLoS Medicine, 2010)
Background: Although antiretroviral therapy (ART) improves survival in persons with cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution inflammatory syndrome (IRIS), an exaggerated and ...
Access to HIV/AIDS care for mothers and children in sub-Saharan Africa: adherence to the postnatal PMTCT program
(Taylor & Francis (Routledge), 2009-09)
Despite scale up of perinatal prevention of mother-to-child transmission (PMTCT) of HIV interventions,postnatal continuity of comprehensive HIV/AIDS care, for both the mother and baby, remains a challenge in developing ...