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Antiretroviral therapy in developing countries: pharmacologic considerations
(Lippincott Williams & Wilkins, 2008)
Purpose of review This article reviews recent studies in the field of clinical pharmacology of antiretroviral drugs and highlights the relevance of the findings to clinical practice in developing countries. Recent findings ...
Prevalence, incidence and predictors of severe anaemia with zidovudine-containing regimens in African adults with HIV infection within the DART trial
(International Medical Press, 2006)
Objective: To describe the prevalence, incidence and predictors of severe anaemia in previously untreated symptomatic HIV-infected adults with CD4+ T-cells <200 cells/mm3 initiating zidovudine-containing regimens in Africa. ...
Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care
(BioMed Central, 2011)
Background: Observational HIV clinic databases are now widely used to answer key questions related to HIV care and treatment, but there has been no systematic evaluation of their quality of data. Our objective was to ...
Potential impact of task-shifting on costs of antiretroviral therapy and physician supply in Uganda
(BMC Health Services Research, 2009-01-09)
Background Lower-income countries face severe health worker shortages. Recent evidence suggests that this problem can be mitigated by task-shifting—delegation of aspects of health care to less specialized health workers. ...
Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?
(African Health Sciences, 2008-06)
Introduction: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this ...
HIV immune reconstitution syndrome in sub-Saharan Africa
(Lippincott Williams & Wilkins, 2008)
Over the last 5 years, there has been remarkable progress
in providing HAART to patients in developing countries.
In sub-Saharan Africa alone, the number receiving antiretroviral
therapy (ART) has more than doubled in ...
Assessment of the patient flow at the infectious diseases institute out-patient clinic, Kampala, Uganda
(Taylor & Francis (Routledge), 2007)
In order to cope with the increasing patient load, a study was performed to identify bottlenecks in patient flow at the Infectious Diseases out-patient clinic in Kampala, Uganda on 10 January 2005. On a standardised ...
Comments on: predictors of immune recovery and the association with late mortalty while on antiretroviral treatment in Cambodia.
(Elsevier, 2012)
We read with great interest the article by van Griensven and Thai, who report on the risk factors for late mortality after antiretroviral therapy (ART) initiation in a cohort of 2840 patients in Cambodia. The main risk ...
Developing independent investigators for clinical research relevant for Africa
(BioMed Central, 2012)
Sustainable research capacity building requires training individuals at multiple levels within a supportive institutional infrastructure to develop a critical mass of independent researchers. At many African medical ...
Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapy
(Public Library of Science, 2012-04-19)
Background: Accurate, inexpensive point-of-care CD4+ T cell testing technologies are needed that can deliver CD4+ T cell results at lower level health centers or community outreach voluntary counseling and testing. We ...