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Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection
(International Medical Press, 2012)
BACKGROUND:
Here, we aimed to determine the clinical spectrum, predictors and outcomes of paradoxical tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in a resource-limited setting.
METHODS:
In a ...
Comments on: predictors of immune recovery and the association with late mortalty while on antiretroviral treatment in Cambodia.
(Elsevier, 2012)
We read with great interest the article by van Griensven and Thai, who report on the risk factors for late mortality after antiretroviral therapy (ART) initiation in a cohort of 2840 patients in Cambodia. The main risk ...
Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapy
(Public Library of Science, 2012-04-19)
Background: Accurate, inexpensive point-of-care CD4+ T cell testing technologies are needed that can deliver CD4+ T cell results at lower level health centers or community outreach voluntary counseling and testing. We ...
Sub-optimal vitamin B-12 levels among ART-Naïve HIV positive individuals in an urban cohort in Uganda
(Public Library of Science, 2012-07-02)
Malnutrition is common among HIV-infected individuals and is often accompanied by low serum levels of micronutrients. Vitamin B-12 deficiency has been associated with various factors including faster HIV disease progression ...
Adherence to antiretroviral therapy in HIV-positive adolescents in Uganda assessed by multiple methods a prospective cohort study
(Adis, 2012-10)
Background: The effectiveness of traditional adherence measurements used in adolescent populations isdifficult to assess. Antiretroviral (ARV) adherence research among adolescents living with HIV in resourceconstrained ...
Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
(Oxford University Press, 2012)
Objectives: Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug–drug interactions between artemether/lumefantrine and efavirenz ...
Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV infected patients
(Public Library of Science, 2012-06-26)
Background: Peripheral blood interferon-gamma release assays (IGRAs) have sub-optimal sensitivity and specificity for diagnosis of active pulmonary tuberculosis (TB). However, assessment of local immune responses has been ...
Impact of antiretroviral therapy on the incidence of Kaposi’s sarcoma in resource-rich and resource-limited settings
(Lippincott, Williams & Wilkins, 2012)
Purpose of review
Given the recent availability of antiretroviral therapy (ART) in resource-limited settings and the significant burden exacted by Kaposi’s sarcoma in these areas, we reviewed data regarding the impact of ...
Rifampicin for continuation phase tuberculosis treatment in Uganda: a cost-effectiveness analysis
(Public Library of Science, 2012-06)
Background: In Uganda, isoniazid plus ethambutol is used for 6 months (6HE) during the continuation treatment phase of new tuberculosis (TB) cases. However, the World Health Organization (WHO) recommends using isoniazid ...
Integration of HIV and TB services results in improved TB treatment outcomes and earlier prioritized ART initiation in a large urban HIV clinic in Uganda
(Lippincott, Williams & Wilkins, 2012-06-01)
Background: The World Health Organization recommends that treatment of tuberculosis ...