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Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda

Bukirwa, Hasifa; Talisuna, Ambrose; Yeka, Adoke; Kamya, Moses R; Talisuna, Ambrose O.; Banek, Kristin; Bakyaita, Nathan; Rwakimari, John Bosco; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant; Staedke, Sarah G. (Public Library of Science, 2006-05)

Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ...

Community effectiveness of malaria treatment in Uganda: a long way to Abuja targets

Nsungwa-Sabiiti, Jesca; Tomson, Goran; Pariyo, George; Ogwal-Okeng, Jasper; Peterson, Stefan (Taylor & Francis, 2005)

Introduction: At the Roll Back Malaria summit for African countries in Abuja, the heads of state committed to ensure that by the year 2005 at least 60% of those suffering from malaria would have access to effective treatment ...

Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.

Sulggi, Less A.; Nsobya, Samuel L.; Yeka, Adoke; Dokomajilar, Christian; Rosenthal, Philip J.; Talisuna, Ambrose; Dorsey, Grant (University of Chicago Press, 2006-03-13)

Malaria infections in Africa frequently include multiple parasite strains.We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies ...

Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.

Nsobya, Samuel L.; Kiggundu, Moses; Joloba, Moses; Dorsey, Grant; Rosentha, Philip J. (University of Chicago Press, 2008-08-22)

We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ...

Delayed care seeking for fatal pnemonia in children aged under five years in Uganda: a case-series study

Källander, Karin; Peterson, Stefan; Pariyo, George; Tomson, Goran; Nsabagasani, Xavier; Sabiiti, Jesca Nsungwa (World Health Organization, 2008)

Objective To review individual case histories of children who had died of pneumonia in rural Uganda and to investigate why these children did not survive. Methods This case-series study was done in the Iganga/Mayuge ...

Short report: assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda

Bukirwa, Hasifa; Yau, Vincent; Kigozi, Ruth; Filler, Scott; Quick, Linda; Lugemwa, Myers; Dissanayake, Gunawardena; Kamya, Moses; Wabwire-Mangen, Fred; Dorsey, Grant (American Society of Tropical Medicine and Hygiene, 2009)

A single round of indoor residual spraying (IRS) using lambda-cyhalothrin was implemented in a district of Uganda with moderate transmission intensity in 2007. Individual patient data were collected from one health facility ...

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.

Kamya, Moses.R; Yeka, Adoke; Bukirwa, Hasifa; Lugemwa, Myers; Rwakimari, John B.; Staedke, Sarah G.; Talisuna, Ambrose O.; Greenhouse, Bryan; Nosten, Francois; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant (2007-05-18)

Objectives: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. Design: Randomized single-blinded clinical ...

Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda

Yeka, Adoke; Kamya, Moses R.; Dorsey, Grant; Talisuna, Ambrose; Lugemwa, Myers; Rwakimari, John Bosco; Staedke, Sarah G.; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Bukirwa, Hasifa (Public Library of Science, 2008-06)

Background: Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ...

Chlorproguanil-dapsone for treating uncomplicated malaria (Review)

Bukirwa, H.; Critchley, J.A; Garner, P. (JohnWiley & Sons, 2010)

Background In Africa, malaria is often resistant to chloroquine and sulfadoxine-pyrimethamine. Chlorproguanil-dapsone is a potential alternative. Objectives To compare chlorproguanil-dapsone with other antimalarial drugs ...

Can community health workers and caretakers recognise pneumonia in children? Experiences from Western Uganda

Källander, Karin; Tomson, Göran; Nsabagasanic, Xavier; Nsungwa-Sabiiti, Jesca; Pariyo, George; Peterson, Stefan (Elsevier, 2006)

Acute respiratory infections (ARI) are leading killers of children. Case management using community health workers (CHW) has halved ARI mortality in children in Asia. WHO/UNICEF recommend integrating pneumonia into Home ...