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Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.
(University of Chicago Press, 2008-08-22)
We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ...
Effect of HIV-1 infection on malaria treatment outcome in Uganda patients
(Makerere University Medical School, 2007)
Background: Malaria and HIV-1 infection cause significant morbidity and mortality in sub-Saharan Africa. HIV-1 increases risk for malaria with the risk increasing as immunity declines. The effect of HIV-1 infection on ...
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
(Oxford University Press, 2009-11-04)
Background. Amodiaquine (AQ) is paired with artesunate (AS) or sulfadoxine-pyrimethamine (SP) in recommended antimalarial regimens. It is unclear how readily AQ resistance will be selected with combination chemotherapy. ...
Chlorproguanil-dapsone for treating uncomplicated malaria (Review)
(JohnWiley & Sons, 2010)
Background In Africa, malaria is often resistant to chloroquine and sulfadoxine-pyrimethamine. Chlorproguanil-dapsone is a potential alternative. Objectives To compare chlorproguanil-dapsone with other antimalarial drugs ...
Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
(American Society for Microbiology, 2006-03-08)
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D ...
Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
(University of Chicago Press, 2006-03-13)
Malaria infections in Africa frequently include multiple parasite strains.We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies ...
Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis
(BioMed Central, 2009-08-23)
Background: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of ACT, recently adopted by the World ...
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda
(2005)
The use of combinations of inexpensive drugs for the treatment of malaria in Africa has been proposed as an interim policy while awaiting the widespread availability of more effective regimens. We compared sulfadoxinepyrimethamine ...
Urban malaria: primary caregivers’ knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan children
(Wiley-Blackwell, 2003-08)
Objectives: To assess malaria-related knowledge, attitude and practices (KAP) among primary caregivers, to identify associations between primary caregivers' characteristics and positive KAP towards malaria, and to identify ...
Artesunate plus mefloquine versus mefloquine for treating uncomplicated malaria (Review)
(Cochrane Collaboration, 2010)
Background
Multiple-drug-resistant malaria is widespread, and in South-East Asia resistance is high against nearly all single therapy antimalarial drugs. Here, and in other areas with low malaria transmission, the combination ...