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Pharmacokinetic interactions between chloroquine, sulfadoxine and pyrimethamine and their bioequivalence in a generic fixed-dose combination in healthy volunteers in Uganda
(African Health Sciences, 2006)
Background: A pre-packaged fixed-dose formulation of chloroquine (CQ) and sulfadoxine/pyrimethamine (S/P) combination (Homapak) is widely used for the treatment of falciparum malaria in Ugandan children. It is however a ...
Improved efficacy with amodiaquine instead of chloroquine in sulfadoxine/pyrimethamine combination treatment of falciparum malaria in Uganda: Experience with fixed-dose formulation
(Acta Tropica, 2006)
Amodiaquine (AQ) is an affordable compound, chemically related to chloroquine (CQ) but often effective against CQ resistant Plasmodium falciparum. In Uganda, a pre-packed fixed-dose combination of CQ plus sulfadoxine/pyrimethamine ...
c-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population
(East African Medical Journal, 2006-08)
Objective: To evaluate c-erbB-2 oncoprotein over expression in breast cancer patients of Kyadondo county and also relate this oncoprotein to histological type and grade of the tumour. Design: Cross-sectional study. Setting: ...
Examining the nexus between nature, wealth and power in the Lake George fishery: a case of major actors in the fish product chain
(2006)
This briefing paper arises out of one of ACODE’s current research undertakings meant to influence policy processes in biodiversity conservation through generation of policy relevant information. The main aim of this paper ...
Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
(Public Library of Science, 2006-05)
Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ...
Bacterial aetiology and outcome of severe pneumonia among children aged 2-59 months admitted to the Acute Care Unit, Mulago Hospital
(2006-05)
Introduction: Acute lower respiratory tract infections (ALRI) are a major cause of morbidity and mortality in the "under fives" worldwide, accounting for 10-30% of childhood deaths. Pneumonia contributes up to 50% of all ...
Can community health workers and caretakers recognise pneumonia in children? Experiences from Western Uganda
(Elsevier, 2006)
Acute respiratory infections (ARI) are leading killers of children. Case management using community health workers (CHW) has halved ARI mortality in children in Asia. WHO/UNICEF recommend integrating pneumonia into Home ...
Digital clubbing in tuberculosis – relationship to HIV infection, extent of disease and hypoalbuminemia
(BioMed Central, 2006-03-10)
Background: Digital clubbing is a sign of chest disease known since the time of Hippocrates. Its association with tuberculosis (TB) has not been well studied, particularly in Africa where TB is common. The prevalence of ...
Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
(American Society for Microbiology, 2006-03-08)
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D ...
Assessing country-level efforts to link research to action
(World Health Organization (WHO), 2006-08)
We developed a framework for assessing country-level efforts to link research to action. The framework has four elements. The first element assesses the general climate (how those who fund research, universities, researchers ...