School of Bio-Medical Sciences (Bio-Medical) Collections: Recent submissions
Now showing items 241-260 of 418
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Association of Carbapenemase Genes with Phenotypic Resistance to Carbapenems among Gram Negative Bacteria
(Winnie Binoga, 2019-12-05)BACKGROUND: Carbapenem drugs are the last resort antibacterial agents used in the treatment of Extended Spectrum Beta-Lactamase multi drug resistant Gram negative bacterial infections. Resistance to these drugs is reported ... -
INNATE IMMUNE SYSTEM RECOVERY AFTER LONG TERM ANTIRETROVIRAL THERAPY IN AN AFRICAN COHORT
(Makerere University, 2019-08-30)Background: Restoration of the immune system has been observed in many cohorts worldwide upon initiation of antiretroviral therapy. However, we have reported partial restoration of the T cell subset function despite seven ... -
Prevalence and associated factors for intestinal parasitic infections among primary school children in Karenga Subcounty, Kaabong District
(Makerere University, 2019)Background: Intestinal parasitic infections caused by helminths and protozoa are responsible for considerable morbidity throughout world. We did not know the burden of parasite infections in Karenga Sub county, Kaabong ... -
EVALUATION OF AN IN-HOUSE PROBE-BASED REAL-TIME PCR TEST FOR EARLY INFANT HIV-1 DIAGNOSIS IN UGANDA
(2019)Background: HIV infection remains a problem worldwide, with the majority of the cases being in resource-limited settings. Pediatric HIV testing is lagging with only 43 % of HIV-exposed infants being tested within the ... -
Maternal transfer of immunoglobulin-g (igg) sub-types and its association to immunity against plasmodium falciparum infection among children in a Ugandan birth cohort (Busia-Eastern Uganda)
(2019-11-04)Background: Children in malaria endemic area acquire maternal transferred immunity that is thought to be protective in their early months of life. Maternally transferred antibodies, mainly IgG play a critical role. IgG ... -
Significance of minority HIV-1 X-4-tropic variants, Host CCR5 promoter genotype in predicting paediatric Virological failure
(Makerere University, 2019-11-04)Background By Sept 2018, only 59.3% of all HIV positive children on cART under 5 years were achieving virological suppression compared to 88.4% in the general population in Uganda. However, while its known that a tropism ... -
Antimicrobial Susceptibility and Plasmid Genes Conferring Multi-Drug Resistance among Klebsiella Pneumoniae Isolated from patients attending Mulago National Referral Hospital from 2017 to 2018.
(Makerere University, 2019-11-25)Introduction: Antimicrobial Resistance results from exposure of microorganisms to antimicrobial substances, consequently with the ineffectiveness of treatments and exacerbating the risk of spread to others. Klebsiella ... -
Antimicrobial Susceptibility of 3rd Generation Cephalosporins-Resistant Escherichia coli, Klebsiella pneumoniae and Enterobacter spp Isolates Carried in the Gut of Patients on admission to Mulago Hospital.
(2019-11-20)Background: Resistance to 3rd and 4th generation cephalosporin is on an increase worldwide. These cephalosporins are used in management of severe infections caused by Enterobacteriaceae. The main objective of the study was ... -
GENETIC VARIATIONS WITHIN THE CCR5 PROMOTER REGION AMONG ELITE AND VIREMIC CONTROLLERS IN UGANDA
(2019-11-13)Background: Mechanisms for HIV control among elite and viremic controllers are not fully understood. Although studies conducted in Uganda have reported the existence of these controllers, research has not yet sounded out ... -
DEVELOPMENT AND OPTIMIZATION OF AN IN VITRO METHOD TO FORCE AND SELECT FOR FUNCTIONAL HIV-1 INTERSUBTYPE pol RECOMBINANTS
(Makerere University, 2019-10-22)Introduction Inter subtype recombination in the pol gene of the HIV-1 affects the enzymatic structure and integrity which greatly impacts their function. These may be silent, deleterious or beneficial for the survival ... -
Nasopharyngeal co-colonization and drug resistance patterns of potentially pathogenic bacteria in children attending Mulago assessment centre Pediatric Unit of Mulago National Referral Hospital, Uganda
(Makerere University, 2019-10)Background: The human nasopharynx is colonized by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. These bacteria may cause several diseases, especially in young children. ... -
Renal Lesions At Autopsy Among Adults At Mulago Hospital Over A Five Year Period (2009-2013)
(Makerere University, 2019)Introduction Autopsy is one of the techniques that can be utilized to study disease that didn’t present any suggestive features in life or that was not fully studied in life, and kidney diseases fall in those diseases ... -
AN ASSESSMENT OF UNDERSTANDING OF INFORMATION PROVIDED IN GENETIC RESEARCH AMONG PEOPLE LIVING WITH HIV AT THE INFECTIOUS DISEASES INSTITUTE (IDI)
(Makerere University, 2019-07)Introduction Obtaining informed consent is essential for biomedical research; and for informed consent to be valid, it is imperative that participants understand all the information disclosed to them before making voluntary ... -
Heme Oxygenase-1 and Neopterin Plasma Levels and their role in Distinguishing Active from Latent TB among HIV/TB Co-Infected Patients
(Makerere University, 2019-10-18)Background: Tuberculosis(TB) diagnosis in the presence of HIV co-infection remains challenging. Heme oxygenase 1(HO-1) and neopterin have shown to be as potential biomarkers for TB diagnosis. Infection of macrophages with ... -
Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens
(2019-10)Background Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets. Despite this, cellular and humoral immune responses against schistosomula ... -
Functional host-genetic loci associated with pediatric HIV-disease progression in Uganda and Botswana.
(2019-10-07)Background: According to UNAIDS, HIV/AIDS remains a leading cause of morbidity and mortality in children under the age of 15. Distinct conditions of HIV-disease progression have been observed in different populations ... -
Evaluation of levels of T. cruzi ribosomal P protein homologous antigens and IgG antibodies among patients with Endomyocardial Fibrosis in Mulago Uganda
(Makerere University, 2017-11-22)Endomyocardial Fibrosis (EMF) is a chronic inflammatory disease of the heart whose cause is still unknown yet about 10 to 12 million people are affected worldwide. In Uganda EMF prevalence is about 10-20% of all the cardiac ... -
Establishment of a transformation and regeneration protocol for Uganda’s passion fruit using gus reporter gene
(Makerere university, 2014-10)Declining yields from passion fruit farming due to a number of problems ranging from pests, diseases, environmental stress, low yields, have initiated widespread enterprise abandonment by farmers. Crop improvement efforts ... -
Outcome and factors associated with mortality of neonates with surgical conditions at Mulago National Referral Hospital.
(Makerere University, 2015)Background: Surgery of neonates is a major challenge worldwide and especially in low and middle income countries where mortality due to surgical conditions has remained high. In developed countries, there has been remarkable ... -
The impact of traditional marriage on church marriage among the Acholi in Gulu Cathedral Parish, in the Light of Familiaris Consortio
(Makerere University, 2015-05)Among the Acholi marriage known as nyom is an heterosexual union of a man and a woman following the precepts of the Acholi culture to enable them be officially recognized as husband and wife. The venue for the Acholi ...