Now showing items 1-20 of 423
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Treatment outcomes of isoniazid mono-resistant mycobacterium tuberculosis patients in Uganda: a retrospective cross-sectional study from 2017 to 2022
(Makerere University, 2024-10)Globally, isoniazid-resistant, rifampicin-susceptible TB is estimated to occur in 13.1% (95% confidence interval [CI]: 9.9–16.9%) of new cases and 17.4% (95% CI: 0.5–54.0%) of previously treated cases. Current WHO guidelines ... -
Occurrence of quinolone resistance genes qep, QnrA, QnrB and QnrS in uropathogenic E. coli from female clinical samples at Makerere University College of Health Sciences
(Makerere University, 2022)Drug resistant Escherichia coli (E Coli) is the leading cause of community and hospital acquired urinary tract infections affecting approximate 150 million people each year worldwide. Uropathogenic Escherichia coli (UPEC) ... -
The informed consent process for emergency surgery at public and private hospital surgical emergency units in the urban Ugandan setting
(Makerere University, 2024)Introduction: Informed consent is a process that can have challenges when required for emergency surgery, because the patient might not have the capacity to consent, and consent may be obtained from the next of kin, or ... -
Accuracy of the M-kit absolute concentration method for detection of drug-resistant mycobacterium tuberculosis in Uganda
(Makerere University, 2024)With an increasing incidence of multidrug-resistant tuberculosis (MDR-TB), accurate drug susceptibility testing (DST) of Mycobacterium tuberculosis to first-line and second-line plus new individualized anti-TB drugs has ... -
CD133 protein expression in primary liver cancer; associated demographic and histopathological characteristics in Uganda
(Makerere University, 2024)Primary liver cancer is a leading cause of cancer morbidity and mortality. Globally, it is the 6th most common cancer and the 3rd most common cause of cancer deaths. In Uganda, liver cancer is the 7th most common cancer ... -
A genome-wide association study of blood urea nitrogen levels in the Uganda Genome Resource Cohort
(Makerere University, 2024)Blood urea nitrogen (BUN) is a key biomarker of kidney function, reflecting the balance between urea production and excretion. Elevated BUN levels are associated with impaired kidney function and serve as a diagnostic and ... -
Isoniazid hair drug levels among drug-susceptible pulmonary tuberculosis patients: A study to monitor exposure, adherence and treatment outcomes
(Makerere University, 2024)Background: Tuberculosis (TB) is still a major public health problem globally and in Uganda.Therapeutic drug monitoring (TDM) for TB improves treatment outcomes and mitigates the emergence of drug resistance (DR). Despite ... -
Phenotypic characterization of bacterial species associated with periodontitis among patients attending Makerere, Mengo and Mulago Paramedical Dental Clinics in Kampala, Uganda
(Makerere University, 2024)Periodontitis is a prevalent dental disease often linked to bacterial infections, leading to inflammation and the deterioration of tissues supporting the teeth. The disease caused by pathogenic microbes forming biofilms ... -
Role of killer cell immunoglobulin-like receptors in the functional modulation of NK cell response to HIV-1 viral reservoirs in individuals on antiretroviral therapy
(Makerere University, 2024)Sub-Saharan Africa has two thirds of the global population living with HIV. Uganda has one of the highest burdens of HIV/AIDS globally, with a significant proportion of individuals on antiretroviral therapy. Complete ... -
In silico characterization of peptides for major surface protein 2, rhoptry-associated protein 1, and the vitellogenin receptor as potential vaccine candidates against babesiosis and anaplasmosis
(Makerere University, 2024)Background: Bovine babesiosis and anaplasmosis caused by Babesia bovis and Anaplasma marginale respectively pose significant threats to the livestock industry, particularly in regions where both parasites co-exist. Current ... -
Machine learning and orthology-based design of synergistic drug combinations against aspergillus fumigatus
(Makerere University, 2024)Background: Aspergillus fumigatus is a common fungal species that can cause invasive aspergillosis, particularly in immunocompromised individuals. In Uganda, around 9% of the population suffers from fungal diseases. Drug ... -
Periodontal disease in patients with diabetes mellitus attending Kiruddu National referral Hospital: Prevalence, risk factors, association with glycemic control and insulin resistance
(Makerere University, 2024-12-23)Background: Diabetes mellitus and periodontal disease establish a relationship where one if poorly managed complicates the management of the other. This study set out to describe the association between periodontal diseases ... -
The predictive utility of polygenic risk scores for chronic kidney disease in Africans
(Makerere University, 2024)Background: Genome-wide association studies (GWAS) have significantly expanded our understanding of the genetic basis of kidney function, with most findings reported in individuals of European ancestry. Such biased sampling ... -
Neutralization and antibody-dependent cellular cytotoxicity functions of SARS-CoV-2 Spike-IgG in vaccinated individuals
(Makerere University, 2024)Background: Following the world-wide spread of the SARS-CoV-2 virus during the COVID-19 pandemic, several types of vaccines were rolled out in various countries including Uganda. Studies elsewhere revealed significant ... -
Cytokine profiles of HIV-associated COPD in a Ugandan Cohort
(Makerere University, 2024-11-18)Introduction:COPD is a chronic lung condition characterized by irreversible airflow obstruction and encompasses chronic bronchiolitis and emphysema. Cigarette smoking is the predisposing factor in over 50% of cases but ... -
Development of an antigen agglutination test for rapid screening of COVID-19 in low laboratory capacity and field settings
(MAKERERE UNIVERSITY, 2024-11-29)The transition of COVID-19 from a pandemic to a general disease has highlighted the need for affordable and accessible diagnostic tests to control the spread of SARS-CoV-2. While PCR tests have been the gold standard for ... -
Whole-Genome Sequencing-based characterization of staphylococcus aureus in hospital settings within East Africa
(Makerere University, 2024-12-06)Background: Staphylococus aureus, a Gram-positive facultative anaerobic bacterium, is a prominent pathogen responsible for a wide range of infections, from minor skin conditions to severe, life- threatening diseases. ... -
Performance evaluation of Sanity 2.0 system in detecting high risk Human papillomavirus in Uganda
(Makerere University, 2024)Aim: We aimed to evaluate the performance of the Sanity 2.0 system as a point-of-care screening test for high-risk Human papillomavirus (hr-HPV) using Cobas 4800 as the gold standard. Background: Cervical cancer is a ... -
Bacteremia in hematologic cancer patients with febrile neutropenia in Uganda
(Makerere University, 2024)Background There were 19.3 million new cancer cases and 10 million cancer deaths which occurred in 2020. Compared to high-income countries cancer is a growing public health problem in sub-Saharan Africa, where mortality ... -
Evaluation of the Liofilchem rapid ESBL NP test for the detection of extended spectrum beta-lactamases in Enterobacteriacea in complicated urinary tract infections at Mulago Hospital using direct urine samples
(Makerere University, 2024)Introduction: There is a growing burden of UTIs complicated by drug resistant microorganisms. Antimicrobial resistance (AMR) is a growing global public health threat, with extended- spectrum beta-lactamase (ESBL) producing ...