Browsing School of Bio-Medical Sciences (Bio-Medical) Collections by Subject "ABCB1"

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Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans

Mukonzo, Jackson K; Waako, Paul; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Lippincott Wilkins & Williams, 2010)

Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This ...
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans

Mukonzo, Jackson K; Röshammar, Daniel; Waako, Paul; Andersson, Maria; Fukasawa, Takashi; Milani, Lili; Svensson, Jan Olof; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (The British Pharmacological Society, 2009)

AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ...