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Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisinin combination therapy: complexity of infection during short-term culture and characterization of in vitro sensitivity in Kampala Uganda
Nsobya, Samuel Lubwama (Makerere University, 2010)Background: Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant ... -
Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
Bukirwa, Hasifa; Talisuna, Ambrose; Yeka, Adoke; Kamya, Moses R; Talisuna, Ambrose O.; Banek, Kristin; Bakyaita, Nathan; Rwakimari, John Bosco; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant; Staedke, Sarah G. (Public Library of Science, 2006-05)Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ... -
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
Yeka, Adoke; Kamya, Moses R.; Dorsey, Grant; Talisuna, Ambrose; Lugemwa, Myers; Rwakimari, John Bosco; Staedke, Sarah G.; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Bukirwa, Hasifa (Public Library of Science, 2008-06)Background: Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ...