Browsing by Author "Joloba, Moses L."
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Activation of the gab Operon in an RpoS-Dependent Manner by Mutations That Truncate the Inner Core of Lipopolysaccharide in Escherichia coli
Joloba, Moses L.; Clemmer, Katy M.; Sledjeski, Darren D.; Rather, Philip N. (American Society for Microbiology, 2004-12)The gab operon (gabDTPC) in Escherichia coli functions in the conversion of -aminobutyrate to succinate. One component of gab operon regulation involves the RpoS sigma factor, which mediates activation at high cell density. ... -
Comparison of transformatio frequencies among selected streptococcus pneumoniae serotypes
Joloba, Moses L.; Kidenya, Benson R.; Katabazi, Fred A.; Muwanguzi, Julian K.; Asiimwe, Benon B.; Alarakol, Simon P.; Nakavuma, Jessica L.; Bajaksouzian, Saralee; Windau, Anne; Jacobs, Michael R.; Kateete, David P. (Elsevier, 2010)Although there are over 90 serotypes of Streptococcus pneumoniae, antimicrobial resistance is predominantly found in a limited number of serotypes/serogroups, namely 6, 9, 14, 19 and 23. There is no compelling mechanism ... -
Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic Falciparum Malaria Infections in Uganda
Tukwasibwe, Stephen; Mugenyi, Levi; Mbogo, George W.; Nankoberanyi, Sheila; Maiteki-Sebuguzi, Catherine; Joloba, Moses L.; Nsobya, Samuel L.; Staedke, Sarah G.; Rosenthal, Philip J. (Journal of Infectious Diseases, 2014)We explored associations between Plasmodium falciparum drug resistance–mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective ... -
Evaluation of capilia TB assay for rapid identification of mycobacterium tuberculosis complex in BACTEC MGIT 960 and BACTEC 9120 blood cultures
Muchwa, Christopher; Akol, Joseph; Etwom, Alfred; Morgan, Karen; Orikiriza, Patrick; Mumbowa, Francis; Odong, Paul R.; Kateete, David P; Eisenach, Kathleen D.; Joloba, Moses L. (BioMed Central, 2012)Background: Capilia TB is a simple immunochromatographic assay based on the detection of MPB64 antigen specifically secreted by the Mycobacterium tuberculosis complex (MTC). Capilia TB was evaluated for rapid identification ... -
Incremental yield of serial sputum cultures for diagnosis of tuberculosis among HIV infected smear negative pulmonary TB suspects in Kampala, Uganda
Ssengooba, Willy; Kiwanuka, Noah; Kateete, David P.; Katamba, Achilles; Joloba, Moses L. (PLoS ONE, 2012-05-22)Background: Sputum culture is the gold standard for diagnosis of pulmonary tuberculosis (PTB). Although mostly used for research, culture is recommended by the World Health Organization for TB diagnosis among HIV infected ... -
A metabolic biosignature of early response to anti-tuberculosis treatment
Mahapatra, Sebabrata; Hess, Ann M.; Johnson, John L.; Eisenach, Kathleen D.; DeGroote, Mary A.; Gitta, Phineas; Joloba, Moses L.; Kaplan, Gilla; Walz, Gerhard; Boom, W. Henry; Belisle, John T. (BMC Infectious Diseases, 2014)Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ... -
Pertussis prevalence and its determinants among children with persistent cough in urban Uganda.
Kayina, Vincent; Kyobe, Samuel; Katabazi, Fred A.; Kigozi, Edgar; Okee, Moses; Odongkara, Beatrice; Babikako, Harriet M.; Whalen, Christopher C.; Joloba, Moses L.; Musoke, Philippa M.; Mupere, Ezekiel (PLOS ONE, 2015)Background We determined prevalence of pertussis infection and its associated host and environmental factors to generate information that would guide strategies for disease control. Methods In a cross-sectional study, ... -
The use of Genotype MTBDRplus assay to assess drug resistance of microbacterium tuberculosis isolates from patients in rural Uganda
Bazira, Joel; Asiimwe, Benon B.; Joloba, Moses L.; Bwanga, Fred; Matee, Mecky I (BioMed Central, 2010)Background: Drug resistance levels and patterns among Mycobacterium tuberculosis isolates from newly diagnosed and previously treated tuberculosis patients in Mbarara Uganda were investigated. Methods: We enrolled, ...