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http://hdl.handle.net/123456789/992
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| Title: | Decreased serum opsonic activity against Streptococcus pneumoniae in Human Immunodeficiency Virus–infected Ugandan adults |
| Authors: | Takahashi, Hidehiko
Oishi, Kazunori
Yoshimine, Hiroyuki
Kumatori, Atsushi
Moji, Kazuhiko
Watanabe, Kiwao
Nalwoga, Hawa
Tugume, Sitefano Buguruka
Kebba, Anthony
Mugerwa, Roy
Mugyenyi, Peter
Nagatake, Tsuyoshi |
| Keywords: | Streptococcus pneumoniae
HIV
Adults
Uganda |
| Issue Date: | 2003 |
| Publisher: | University of Chicago Press |
| Citation: | Clinical Infectious Diseases 2003; 37:1534–1540 |
| Abstract: | Type-specific immunoglobulin G (IgG) to pneumococcal capsular polysaccharide (CPS) and opsonic activity against Streptococcus pneumoniae were evaluated in serum samples from 36 Ugandan adults with community acquired pneumonia and 58 asymptomatic Ugandan adults with or without human immunodeficiency virus type 1 (HIV-1) infection. The levels of serum IgG to CPS were significantly higher in HIV-1–infected subjects than in HIV-uninfected subjects. Serum samples from HIV-1–infected subjects that had lower IgG titers demonstrated higher opsonic activity against type 3 (titers of 7) and type 9 (titers of 7–11) pneumococcal strains. Plasma HIV-1 load also correlated inversely with serum opsonic activity against these strains, and peripheral blood CD4+ lymphocyte numbers also tended to correlate with serum opsonic activity in asymptomatic HIV-1–infected adults. Our findings suggest that the opsonic activity of type-specific IgG is impaired in the serum of HIV-1–infected African adults, which may expose them to a serious risk of invasive pneumococcal infections. |
| Description: | © 2003 by the Infectious Diseases Society of America. All rights reserved. |
| URI: | http://www.journals.uchicago.edu/
http://dx.doi.org/10.1086/379511
http://hdl.handle.net/123456789/992 |
| ISSN: | 1058-4838 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| takahashi-chs-res.pdf | | 158Kb | Adobe PDF | View/Open |
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