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|Title: ||Blood-stage dynamics of plasmodium falciparum with and without immune response|
|Authors: ||Nabiyonga, Betty K.|
Luboobi, Livingstone S.
Mugisha, J. Y. T.
Basic reproductive number
|Issue Date: ||2005 |
|Abstract: ||Malaria has continued to be fatal in many areas especially endemic areas. During the life cycle of
the malaria parasite (Plasmodium falciparum) in the human body, different immune cells attack
different stages of the parasite. A simple mathematical model for the human immune response
to malaria parasite (Plasmodium falciparum) is used to analyze the interaction between malaria
parasites and the human immune system and the differentiation of asexual parasites into sexual
parasites, transmissible blood stages. In the analysis of the model, we show that both disease-free
state and persistent state exist and we derive conditions for their stability. Comparison of the
basic reproductive rate in the human host with immunity (Ro) where more merozoites are eliminated
and the basic reproductive in human host without immunity (R0o) is done. It is noted that
Ro < R0o because of the number of asexual parasites eliminated through immune response.|
|Appears in Collections:||Research Articles (Science)|
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