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|Title: ||Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women|
|Authors: ||Nalwoga, Hawa|
Arnes, Jarle B.
Akslen, Lars A.
|Issue Date: ||2008 |
|Citation: ||Nalwoga H., Arnes J. B., Wabinga H., Akslen L. A. (2008). Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women. APMIS; 116:515–25.|
|Abstract: ||Epidermal growth factor receptor (EGFR) and c-kit are tyrosine kinase growth factor receptors which are frequently expressed in basal-like breast carcinomas, and tyrosine kinase inhibition is now a promising strategy in treatment of breast cancer. The aim of this study was to evaluate the expression of EGFR and c-kit in breast cancer with special focus on the basal-like phenotype (BLP) and other prognostic factors in an African population. We analyzed 65 archival tissues immunohistologically. EGFR and/or c-kit were expressed in 55% of basal-like tumors. Expression of EGFR and/or c-kit was strongly associated with high histologic grade (P = 0.001), high nuclear grade (P = 0.017), high mitotic counts (P = 0.002), ER negativity (P = 0.003), PR negativity (P = 0.007), and HER2 negativity (P = 0.014). EGFR and/or c-kit positive tumors were more likely to express the BLP (OR 9.1, CI 2.6–32.0, P < 0.0005) than the negative tumors. In conclusion, there is a high expression of EGFR and/or c-kit in basal-like breast carcinoma in this series from Uganda and their expression is associated with features of poor prognosis. More studies are required to assess the clinical significance of EGFR and c-kit in breast cancer patients in Uganda.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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