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http://hdl.handle.net/123456789/987
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| Title: | Community-acquired pnemonia in Ugandan adults: short-term parenteral ampicilin therapy for bacterial pnemonia |
| Authors: | Yoshimine, Hiroyuki
Oishi, Kazunori
Mubiru, Francis
Nalwoga, Hawa
Takahashi, Hidehiko
Amano, Hideaki
Ombasi, Philip
Watanabe, Kiwao
Joloba, Moses
Aisu, Thomas
Ahmed, Kamruddin
Shimada, Masaaki
Mugerwa, Roy
Nagatake, Tsuyoshi |
| Keywords: | Community-Acquired Pneumonia (CAP)
HIV-1
Parenteral ampicillin |
| Issue Date: | 2001 |
| Publisher: | American Society of Tropical Medicine and Hygiene |
| Citation: | American Journal of Tropical Medicine and Hygiene, 64(3, 4), 2001, pp. 172-177 |
| Abstract: | A hospital-based prospective study of 99 patients with community-acquired pneumonia (CAP) was carried out in Kampala, Uganda. We evaluated microbiological etiologies, clinical features and effectiveness of short-term parenteral ampicillin followed by oral amoxicillin for these patients in relation to HIV-status. We demonstrated a very high prevalence (75%) of HIV-1 infection. No significant difference was observed with respect to age, gender, prior antibiotic usage, symptoms, laboratory data or bacterial etiology between HIV-1-infected and HIV-uninfected CAP patients. Most strains of Streptococcus pneumoniae (n = 19) and Haemophilus influenzae (n = 8) isolated from HIV-1-infected patients were penicillin-resistant (95%) and β-lactamase producing (75%) strains, respectively. A high percentage of good clinical response was found in both HIV-1-infected (81%) and HIV-uninfected (86%) among 39 patients with CAP due to a defined bacterial pathogen. These data support the use of short-term parenteral ampicillin for patients with bacterial CAP irrespective of HIV-status. |
| URI: | http://hdl.handle.net/123456789/987 |
| Appears in Collections: | Research Articles (Health-Sciences)
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