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http://hdl.handle.net/123456789/760
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| Title: | Prevalence of latent and reactivated Toxoplasma gondii parasites in HIV-patients from Uganda |
| Authors: | Lindstrom, Irene
Kaddu-Mulindwa, Deogratias H
Kironde, Fred
Lindh, Johan |
| Keywords: | Toxoplasma gondii
Seroprevalence
PCR
SAG2
HIV
Africa |
| Issue Date: | 8-Dec-2006 |
| Publisher: | Elsevier |
| Citation: | Lindstrom, I., Kaddu-Mulindwa, D. H., Kironde, F. & Lindh, J. (2006). Prevalence of latent and reactivated Toxoplasma gondii parasites in HIV-patients from Uganda. Acta Tropica 100(3): 218–222 |
| Abstract: | Untreated Toxoplasma gondii-infections are often fatal in AIDS-patients. Many African countries struck hard by HIV/AIDS exhibit a high seroprevalence of T. gondii, but the rate of reactivated parasites among African HIV-patients has never previously been determined. In this study, IgG-agglutination and PCR was used to analyse blood samples from 130 HIV-positive patients in Uganda. Anti-T. gondii antibodies were detected in 54% of the patients while 23% had parasites in the peripheral blood, which indicates active infection. Genotyping of the SAG2-locus revealed the type II allele for most disease-causing strains (60%), but all three SAG2-types was represented in our study population. Furthermore, one sample appeared to harbour a recombinant strain, with SAG2 type II but the type I-allele at the BTUB-gene. This study emphasizes the high prevalence of toxoplasmosis among Ugandan HIV-patients and also suggests that recombinant or atypical strains may be present in this part of the world. |
| Description: | © 2006 Elsevier B.V. All rights reserved.
Available online at http://www.sciencedirect.com |
| URI: | http://www.sciencedirect.com
http://dx.doi.org/10.1016/j.actatropica.2006.11.002
http://hdl.handle.net/123456789/760 |
| ISSN: | 0001-706X |
| Appears in Collections: | Research Articles (Bio-Medical)
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| kaddu-mulindwa-chs-res.pdf | HIV-Uganda | 164Kb | Adobe PDF | View/Open |
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