|
Makerere University Research Repository >
College of Health Sciences >
School of Health Sciences >
Research Articles (Health-Sciences) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/743
|
| Title: | Harnessing pharmacogenomics to tackle resistance to the “Nucleoside Reverse Trancripatse Inhibitor” backbone of highly active antiretroviral therapy in resource limited settings |
| Authors: | Wayengera, Misaki
Kajumbula, Henry
Byarugaba, Wilson |
| Keywords: | Acquired immunodeficiency syndrome (AIDS)
Highly Active Antiretroviral Therapy (HAART)
Human Immunodeficiency Virus (HIV)
Drug resistance |
| Issue Date: | 2008 |
| Publisher: | Bentham Science Publishers |
| Citation: | Wayengera, M., Kajumbula, H. & Byarugaba, W. (2008). Harnessing pharmacogenomics to tackle resistance to the “Nucleoside Reverse Trancripatse Inhibitor” backbone of highly active antiretroviral therapy in resource limited settings. The Open AIDS Journal, 2: 78-81 |
| Abstract: | Background: The sustainable use of HAART within the sub-Saharan and other developing world settings faces the emerging challenge of drug resistance. Nucleoside reverse transcriptase inhibitors (NRTI) form the backbone of HAART and preserving their “antiviral efficacy” is thus critical to sustainable HAART use.
Methods: A systematic review of the “mechanisms of evolution” of resistance to NRTI at the HIV genome level, and the phenotypic manifestations on drug pharmacokinetics was done.
Conclusion: This paper provides an evidence based account of how the knowledge of pharmacogenomics may be exploited to tackle NRTI resistance within limited resource. |
| Description: | The original publication is available at http://www.bentham.org/open/toaidj/index.htm |
| URI: | http://www.bentham.org/open/toaidj/index.htm
http://dx.doi.org/10.2174/1874613600802010078
http://hdl.handle.net/123456789/743 |
| ISSN: | 1874-6136 |
| Appears in Collections: | Research Articles (Health-Sciences)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| wayengera-kajumbula-byarugaba-chs-res.pdf | | 66Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
