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http://hdl.handle.net/123456789/265
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| Title: | Modelling the immune system response to plasmodium falciparon |
| Authors: | Nabiyonga, Betty K. |
| Keywords: | Immune system
Plasmodium falciparum |
| Issue Date: | 15-Dec-2008 |
| Abstract: | Malaria has continued to be fatal in many areas especially mosquito endemic areas. During the lifecycie of the malaria parasite (Plasmodium falciparum) in the human body, different immune cells attack different stages of the parasite. A simple differential-equation based mathematical model for the human immune response to malaria parasite (Plasmodium falciparum) is used to analyze the interaction between malaria parasites and the human immune system and the differentiation of asexual parasites into sexuai parasites, the transmissible blood stages. In the analysis of the model, we show that both disease-free and endemic equilibrium points exist and we derive conditions for their stability. It was found that higher gametocyte differentiation rate from asexual form of the parasite results in a lower peak parasiteamia, and that the stronger the immune response implying that the higher the elimination rate of infected erythrocytes, the less the effective number of merozoites. Also with a small number of merozoites released per dying infected erythrocytes, less erythrocytes will be infected. This is a good condition {or disease-free equilibrium to be achieved.
Comparison of the basic reproductive rate in the human host with immunity (Ro) where
more merozoites are eliminated and the basic reproductive in human host without immunity (Ro) is done. It is shown that Ro < Ro', because of the number of asexual parasites eliminated through immune response. |
| URI: | http://hdl.handle.net/123456789/265 |
| Appears in Collections: | Theses & Dissertations (Science)
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Files in This Item:
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Description |
Size | Format |
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| nabiyonga-science-masters.pdf | Immune system | 3291Kb | Adobe PDF | View/Open |
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