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|Title: ||Rates of anti-tuberculosis drug resistance in Kampala- Uganda are low and not associated with HIV infection|
|Authors: ||Lukoye, Deus|
Cobelens, Frank G.J.
Adatu, Francis E.
Lule, Joseph K.
Joloba, Moses L.
Drug resistance diseases
|Issue Date: ||10-Jan-2011 |
|Publisher: ||Public Library of Science|
|Citation: ||Lukoye, D., Cobelens, F.G.J., Ezati, N., Kirimunda, S., Adatu, F.E., Lule, J.K., Nuwaha, F., Joloba, M.L. (2011). Rates of anti-tuberculosis drug resistance in Kampala- Uganda are low and not associated with HIV infection. PLoS ONE 6(1).|
|Abstract: ||Background: Drug resistance among tuberculosis patients in sub-Saharan Africa is increasing, possibly due to association
with HIV infection. We studied drug resistance and HIV infection in a representative sample of 533 smear-positive
tuberculosis patients diagnosed in Kampala, Uganda.
Methods/Principal Findings: Among 473 new patients, multidrug resistance was found in 5 (1.1%, 95% CI 0.3–2.5) and
resistance to any drug in 57 (12.1%, 9.3–15.3). Among 60 previously treated patients this was 7 (11.7%, 4.8–22.6) and 17
(28.3%; 17.5–41.4), respectively. Of 517 patients with HIV results, 165 (31.9%, 27.9–36.1) tested positive. Neither multidrug
(adjusted odds ratio (ORadj) 0.7; 95% CI 0.19–2.6) nor any resistance (ORadj 0.7; 0.43–1.3) was associated with HIV status.
Primary resistance to any drug was more common among patients who had worked in health care (ORadj 3.5; 1.0–12.0).
Conclusion/Significance: Anti-tuberculosis drug resistance rates in Kampala are low and not associated with HIV infection,
but may be associated with exposure during health care.|
|Appears in Collections:||Research Articles (Bio-Medical)|
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