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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1934
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| Title: | Rates of anti-tuberculosis drug resistance in Kampala- Uganda are low and not associated with HIV infection |
| Authors: | Lukoye, Deus
Cobelens, Frank G.J.
Ezati, Nicholas
Kirimunda, Samuel
Adatu, Francis E.
Lule, Joseph K.
Nuwaha, Fred
Joloba, Moses L. |
| Keywords: | HIV/AIDS
Drug resistance diseases
Tuberculosis
Sub-Saharan Africa
Antiretroviral treatment
HIV Testing |
| Issue Date: | 10-Jan-2011 |
| Publisher: | Public Library of Science |
| Citation: | Lukoye, D., Cobelens, F.G.J., Ezati, N., Kirimunda, S., Adatu, F.E., Lule, J.K., Nuwaha, F., Joloba, M.L. (2011). Rates of anti-tuberculosis drug resistance in Kampala- Uganda are low and not associated with HIV infection. PLoS ONE 6(1). |
| Abstract: | Background: Drug resistance among tuberculosis patients in sub-Saharan Africa is increasing, possibly due to association
with HIV infection. We studied drug resistance and HIV infection in a representative sample of 533 smear-positive
tuberculosis patients diagnosed in Kampala, Uganda.
Methods/Principal Findings: Among 473 new patients, multidrug resistance was found in 5 (1.1%, 95% CI 0.3–2.5) and
resistance to any drug in 57 (12.1%, 9.3–15.3). Among 60 previously treated patients this was 7 (11.7%, 4.8–22.6) and 17
(28.3%; 17.5–41.4), respectively. Of 517 patients with HIV results, 165 (31.9%, 27.9–36.1) tested positive. Neither multidrug
(adjusted odds ratio (ORadj) 0.7; 95% CI 0.19–2.6) nor any resistance (ORadj 0.7; 0.43–1.3) was associated with HIV status.
Primary resistance to any drug was more common among patients who had worked in health care (ORadj 3.5; 1.0–12.0).
Conclusion/Significance: Anti-tuberculosis drug resistance rates in Kampala are low and not associated with HIV infection,
but may be associated with exposure during health care. |
| URI: | doi:10.1371/journal.pone.0016130
http://hdl.handle.net/123456789/1934 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Research Articles (Bio-Medical)
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