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http://hdl.handle.net/123456789/1929
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| Title: | Zinc status in HIV infected Ugandan children aged 1-5 years: a cross sectional baseline survey |
| Authors: | Ndeezi, Grace
Tumwine, James K.
Bolann, Bjørn J.
Ndugwa, Christopher M.
Tylleskär, Thorkild |
| Keywords: | HIV/AIDS
Children
Africa
HAART
Antiretroviral therapy |
| Issue Date: | 2010 |
| Publisher: | BioMed Central |
| Citation: | Ndeezi, G., Tumwine, J.K., Bolann, B.J., Ndugwa, C.M., Tylleskär, T. (2010). Zinc status in HIV infected Ugandan children aged 1-5 years: a cross sectional baseline survey. BMC Pediatrics, 10(68) |
| Abstract: | Background: Low concentrations of serum zinc have been reported in HIV infected adults and are associated with
disease progression and an increased risk of death. Few studies have been conducted in HIV infected children in
Africa. We determined serum zinc levels and factors associated with zinc deficiency in HIV infected Ugandan
children.
Methods: We measured the baseline zinc status of 247 children aged 1-5 years enrolled in a randomised trial for
multiple micronutrient supplementation at paediatric HIV clinics in Uganda (http://ClinicalTrials.gov NCT00122941).
Zinc status was determined using inductively coupled atomic emission spectrophotometry (ICP-AES). Clinical and
laboratory characteristics were compared among zinc deficient (zinc <10.0 μmol/L) and non deficient children.
Logistic regression was used to determine predictors of low serum zinc.
Results: Of the 247 children, 134 (54.3%) had low serum zinc (< 10.0 μmol/L). Of the 44 children on highly active
antiretroviral therapy (HAART), 13 (29.5%) had low zinc compared to 121/203 (59.6%) who were not on HAART.
Overall, independent predictors of low zinc were fever (OR 2.2; 95%CI 1.1 - 4.6) and not taking HAART (OR 3.7; 95%
CI 1.8 - 7.6).
Conclusion: Almost two thirds of HAART naïve and a third of HAART treated HIV infected children were zinc
deficient. Increased access to HAART among HIV infected children living in Uganda might reduce the prevalence of
zinc deficiency. |
| URI: | http://www.biomedcentral.com/1471-2431/10/68
http://hdl.handle.net/123456789/1929 |
| ISSN: | 1471-2431 |
| Appears in Collections: | Research Articles (Health-Sciences)
|
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| Ndeezi-chs-res.pdf | | 346Kb | Adobe PDF | View/Open |
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