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| Title: | Use of artemisia annua L. infusion for malaria prevention: mode of action and benefits in a Ugandan community |
| Authors: | Ogwang, Patrick E
Ogwal, Jasper O
Kasasa, Simon
Ejobi, Francis
Kabasa, David
Obua, Celestino |
| Keywords: | Malaria prevention
Artemisia annua
Uganda
Flavonoids
Antimalarial treatment |
| Issue Date: | 2011 |
| Publisher: | SCIENCEDOMAIN International |
| Citation: | Ogwang, P.E., Ogwal, J.O., Kasasa, S., Ejobi, F., Kabasa, D., Obua, C. (2011). Use of artemisia annua L. infusion for malaria prevention: mode of action and benefits in a Ugandan community. British Journal of Pharmaceutical Research, 1(4) |
| Abstract: | Malaria is major public health problem in Uganda endemic in 95% contributing up to
40% of hospital outpatient attendances. Approaches to controlling the disease include;
environmental, entomological and medicinal interventions. Some communities use
medicinal plants to control the disease. In this paper we report the use of Artemisia
annua L. for malaria prophylaxis at a Ugandan floricultural farm. We conducted a survey
of the farm workers to determine extent of use of A. annua ‘tea’, their clinic attendance
patterns and also quantified the levels of artemisinin and flavonoids in A. annua. We
further tested the effect of artemisinin devoid extract in laboratory animal models.
Findings from the survey showed that 84.2% of the managers and 62% of field workers
in this farm consumed A. annua ‘tea’ once a week to prevent malaria and related fevers.
Clinic attendance due to fevers or symptoms associated with malaria was reduced by
80% while cases of laboratory confirmed diagnosis of malaria reduced by 16.7%.
Laboratory test of A. annua leaf powder used in community indicated the presence of
artemisinin (0.4% to 0.5%) and flavonoids (9% to 11%). A. annua extract devoid of
artemisinin was found to significantly boost monocyte counts in albino rats (p<0.001).The action of these flovonoids could explain the mechanism of prophylaxis of
A. annua ‘tea’. A. annua variety or product thereof rich in flavonoids but devoid of
artemisinin should be developed and tried for mass prevention of malaria as a beverage
or food taken regularly. |
| URI: | http://hdl.handle.net/123456789/1916 |
| ISSN: | 2231-2919 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| Ogwang-chs-res.pdf | | 804Kb | Adobe PDF | View/Open |
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