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http://hdl.handle.net/123456789/1905
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| Title: | Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda |
| Authors: | Nakawesi, Jane S.
Wobudeya, Eric
Ndeezi, Grace
Mworozi, Edison A.
Tumwine, James K. |
| Keywords: | Diarrhea
Rotavirus
Children
Developing countries
Malnutrition
Uganda
HIV/AIDS |
| Issue Date: | 2010 |
| Publisher: | BioMed Central |
| Citation: | Nakawesi, J.S., Wobudeya, E., Ndeezi, G., Mwrorozi, E.A., Tumwine, J.K. (2010). Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda. BMC Pediatrics, 10(69) |
| Abstract: | Background: Rotavirus remains the commonest cause of severe dehydrating diarrhea among children worldwide.
Children in developing countries die more because of several factors including poorer access to hydration therapy
and greater prevalence of malnutrition. Hitherto, the magnitude of rotavirus disease in Uganda has remained
unknown. This study was therefore done to determine the prevalence and factors associated with rotavirus
infection among children aged 3-59 months admitted with acute diarrhea to paediatric emergency ward of
Mulago Hospital, Uganda
Methods: Three hundred and ninety children, aged between 3-59 months with acute diarrhoea were recruited.
The clinical history, socio-demographic characteristics, physical examination findings and laboratory investigations
were recorded. Stool samples were tested for rotavirus antigens using the DAKO IDEIA rotavirus EIA detection kit.
Results: The prevalence of rotavirus infection was 45.4%. On multivariate analysis rotavirus was significantly
associated with a higher education (above secondary) level of the mother [OR 1.8; 95% CI 1.1-2.7]; dehydration [OR
1.8; 95% CI 1.1-3.0] and breastfeeding [OR 2.6; 95% CI 1.4-4.0]. Although age was significantly associated with
rotavirus on bivariate analysis; this association disappeared on multivariate analysis. No significant association was
found between rotavirus infection and nutritional status, HIV status and attendance of day care or school.
Conclusions: Rotavirus infection is highly prevalent among children with acute diarrhoea admitted to Mulago
Hospital in Uganda. |
| URI: | http://www.biomedcentral.com/1471-2431/10/69
http://hdl.handle.net/123456789/1905 |
| ISSN: | 1471-2431 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| nakawesi-chs-res.pdf | | 159Kb | Adobe PDF | View/Open |
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