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|Title: ||Total lymphocyte count: not a surrogate marker for risk of death in HIV infected Ugandan children|
|Authors: ||Musoke, Philippa M.|
Young, Alicia M.
Lubega, Irene R.
Brown, Elizabeth R.
Mmiro, Francis A.
Mofenson, Lynne M.
Jackson, J. Brooks
Fowler, Mary Glenn
Guay, Laura A.
|Keywords: ||Total Lymphocyte Count|
CD4 cell count
|Issue Date: ||2008 |
|Publisher: ||Lippincott, Williams & Wilkins|
|Citation: ||Musoke. P.M., Owor, M., Young, A.M., Lubega, I.R., Brown, E.R., Mmiro, F.A., Mofenson, L.M., Jackson, J.B., Fowler, M.G., Guay, L.A. (2008). Total lymphocyte count: not a surrogate marker for risk of death in HIV infected Ugandan children. Journal of Acquired Immune Deficiency Syndromes, 49(2)|
|Abstract: ||Objectives—To determine the utility of Total Lymphocyte Count (TLC) in predicting the 12 month mortality in HIV infected Ugandan children; to correlate TLC and CD4 cell %.
Design—This is a retrospective data analysis of clinical and laboratory data collected prospectively
on 128 HIV infected children in the HIVNET 012 trial.
Methods—TLC and CD4 cell % measurements were obtained at birth, 14 weeks and 12, 24, 36,
48, and 60 months of age and assessed with respect to risk of death within 12 months.
Results—Median TLC/ul (CD4 cell %) were 4150 (41%) at birth, 4900 (24%) at 12 months, 4300
(19%) at 24 months, 4150 (19 %) at 36 months, 4100 (18%) at 48 months and 3800 (20%) at 60
months. The highest risk of mortality within 12 months was 34–37% at birth and declined to 13–
15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC
was extremely low overall (r = 0.01).
Conclusion—The TLC did not predict a risk of progression to death within 12 months and therefore
TLC alone may not be a useful surrogate marker for determining those children in greatest need for antiretroviral therapy in HIV infected Ugandan children.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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