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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1898
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| Title: | Total lymphocyte count: not a surrogate marker for risk of death in HIV infected Ugandan children |
| Authors: | Musoke, Philippa M.
Owor, Maxensia
Young, Alicia M.
Lubega, Irene R.
Brown, Elizabeth R.
Mmiro, Francis A.
Mofenson, Lynne M.
Jackson, J. Brooks
Fowler, Mary Glenn
Guay, Laura A. |
| Keywords: | Total Lymphocyte Count
HIV/AIDS
Africa
Children
Mortality
CD4 cell count |
| Issue Date: | 2008 |
| Publisher: | Lippincott, Williams & Wilkins |
| Citation: | Musoke. P.M., Owor, M., Young, A.M., Lubega, I.R., Brown, E.R., Mmiro, F.A., Mofenson, L.M., Jackson, J.B., Fowler, M.G., Guay, L.A. (2008). Total lymphocyte count: not a surrogate marker for risk of death in HIV infected Ugandan children. Journal of Acquired Immune Deficiency Syndromes, 49(2) |
| Abstract: | Objectives—To determine the utility of Total Lymphocyte Count (TLC) in predicting the 12 month mortality in HIV infected Ugandan children; to correlate TLC and CD4 cell %.
Design—This is a retrospective data analysis of clinical and laboratory data collected prospectively
on 128 HIV infected children in the HIVNET 012 trial.
Methods—TLC and CD4 cell % measurements were obtained at birth, 14 weeks and 12, 24, 36,
48, and 60 months of age and assessed with respect to risk of death within 12 months.
Results—Median TLC/ul (CD4 cell %) were 4150 (41%) at birth, 4900 (24%) at 12 months, 4300
(19%) at 24 months, 4150 (19 %) at 36 months, 4100 (18%) at 48 months and 3800 (20%) at 60
months. The highest risk of mortality within 12 months was 34–37% at birth and declined to 13–
15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC
was extremely low overall (r = 0.01).
Conclusion—The TLC did not predict a risk of progression to death within 12 months and therefore
TLC alone may not be a useful surrogate marker for determining those children in greatest need for antiretroviral therapy in HIV infected Ugandan children. |
| URI: | doi:10.1097/QAI.0b013e318183a92a.
http://hdl.handle.net/123456789/1898 |
| ISSN: | 1525-4135 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| musoke-chs-res.pdf | | 310Kb | Adobe PDF | View/Open |
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