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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1891
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| Title: | Response to antiretroviral therapy in HIV-infected Ugandan children exposed and not exposed to single-dose nevirapine at birth |
| Authors: | Musoke, Philippa M.
Barlow-Mosha, Linda
Bagenda, Danstan
Mudiope, Peter
Mubiru, Michael
Ajuna, Patrick
Tumwine, James K.
Fowler, Mary Glenn |
| Keywords: | HIV/AIDS
Children
Nevirapine exposure
Highly active antiretroviral therapy
HAART
Uganda
Antiretroviral therapy |
| Issue Date: | 2009 |
| Publisher: | Lippincott, Williams & Wilkins |
| Citation: | Musoke, P.M., Barlow-Mosha, L.M., Bagenda, D., Mudiope, P., Mubiru, M.M., Ajuna, P., Tumwine, J.K., Fowler, M.G. (2009). Response to antiretroviral therapy in HIV-infected Ugandan children exposed and not exposed to single-dose nevirapine at birth. Journal of Acquired Immune Deficiency Syndromes, 52(5) |
| Abstract: | Objective: To compare the response to a nevirapine (NVP)–based
highly active antiretroviral therapy (HAART) in HIV-infected
Ugandan children, exposed and nonexposed to single-dose NVP
(sd NVP) at birth.
Methods: HIV-infected study children were initiated on stavudine/
lamivudine/NVP as a fixed dose combination. CD4 cell percent
and HIV-1 RNA were documented at baseline, 12, 24, 36, and 48
weeks post-initiation of HAART.
Results: Ninety-two children were enrolled in the study, 44 in the sd
NVP–exposed and 48 in the nonexposed cohort. The median age at
enrollment was 1.7 years [interquartile range (IQR) 1.2–2.4] and 7.8
years (IQR 5.9–9.2) in the sd NVP–exposed and nonexposed cohorts,
respectively (P , 0.001). At baseline and week 48 post-HAART, the
median CD4 cell percentages were 14% and 33% for the NVPexposed
group and 8% and 22.5% in the nonexposed group (P ,
0.0001). The median (IQR) viral load at baseline was 650,568
(359,979–2,086,613) RNA copies/mL and 239,027 (105,904–
494,813) RNA copies/mL in the NVP-exposed and nonexposed
cohorts, respectively. After 48 weeks of HAART, 76% of the NVPexposed
and 80% of the nonexposed children had a median viral load
of ,400 copies/mL (P = 0.74).
Conclusions: Both HIV-infected Ugandan older infants and children that were exposed and not exposed to sd NVP at birth had favorable treatment outcomes on NVP-containing HAART. |
| URI: | http://hdl.handle.net/123456789/1891 |
| ISSN: | 1525-4135 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| musoke-chs-res.pdf | | 346Kb | Adobe PDF | View/Open |
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