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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1867
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| Title: | Prevalence, incidence and clearance of human papillomavirus infection among |
| Authors: | Banura, Cecily
Franceschi, Silvia
van Doorn, Leen-Jan
Arslan, Annie
Kleter, Bernhard
Wabwire-Mangen, Fred
Mbidde, Edward K.
Quint, Wim
Weiderpass, Elisabete |
| Keywords: | Human papillomavirus
Pregnant adolescents
HIV
Uganda
Epidemiology |
| Issue Date: | 2008 |
| Publisher: | Wiley-Liss Inc. |
| Citation: | Banura, C. et al. (2008). Prevalence, incidence and clearance of human papillomavirus infection among. Int. J. Cancer, 123: 2180–2187 |
| Abstract: | The proportion of women who have already been exposed to
human papillomavirus (HPV) infection by the time they first
become pregnant, and the influence of pregnancy and delivery on
the course of HPV infection are unclear. In Kampala, Uganda,
987 young primiparous pregnant women aged <25 years had
gynaecological examination and liquid-based cytology. In the follow-
up, women acted as their own controls, i.e., 1st/2nd versus 3rd
trimesters (105 women), and during pregnancy versus after delivery
(289 women). HPV was assessed using highly sensitive PCR
assays. Prevalence of HPV and HIV infections at baseline were
60.0% and 7.3%, respectively. HPV16 and 18 were detected in
8.4% and 5.8%, respectively, i.e., less frequently than HPV51
(8.7%) and 52 (12.1%). At follow-up new HPV infections were
detected in 42.9% of women between the 1st/2nd and 3rd trimesters,
and 38.1% between pregnancy and delivery, but 50.4% and
71.8% of HPV infections, respectively, cleared, leaving HPV prevalence
unchanged in the different periods. Prevalence of cytological
abnormalities diminished after delivery (from 21.2% to
12.4%). Presence of genital warts and sexually transmitted infections
other than HPV were the strongest risk factors for prevalent
or incident HPV infection. Clearance was lower among HIV-positive
women. In conclusion, HPV prevalence was high in primiparous
women in Uganda, but pregnancy did not seem to be a period
of special vulnerability to the infection. |
| URI: | http://dx.doi.org/10.1002/ijc.23762
http://hdl.handle.net/123456789/1867 |
| ISSN: | 0020-7136 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| Banura-chs-res.pdf | | 180Kb | Adobe PDF | View/Open |
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