|
Makerere University Research Repository >
College of Health Sciences >
Infectious Diseases Institute >
Research Articles (IDI) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1852
|
| Title: | Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources |
| Authors: | Colebunders, R
John, L
Huyst, V
Kambugu, A
Scano, F
Lynen, L |
| Keywords: | HIV infection
Mycobacterium tuberculosis
Antiretroviral treatment
Immune reconstitution inflammatory syndrome
HIV/AIDS
TB
Tuberculosis |
| Issue Date: | 2006 |
| Publisher: | International Union Against Tuberculosis and Lung Disease |
| Citation: | Colebunders, R. John, L., Huyst, V., Kambugu, A., Scano, F., Lynen, L. (2006).Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources. International Journal of Tuberculosis and Lung Disease,10(9). |
| Abstract: | Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome
(IRIS) events, particularly in developing countries where
HIV and tuberculosis (TB) co-infection is very common. Small cohort studies of HIV-positive patients with active
TB treated with antiretroviral therapy (ART) suggest an
incidence of TB IRIS varying between 11% and 45%.Risk factors for TB IRIS that have been suggested in certain
studies but not in others include: starting ART within 6 weeks of starting TB treatment; extra-pulmonary or disseminated disease; a low CD4 lymphocyte count and a high viral load at the start of ART; and a good immunological and virological response during highly active antiretroviral therapy (HAART). It is important to agree on a clinical case definition of TB IRIS that could be used in resource-limited settings. Such a case definition
could be used to determine the exact incidence and consequences of TB IRIS and would be valuable worldwide
in clinical trials that are needed to answer questions on how this phenomenon could be prevented and treated. |
| URI: | http://hdl.handle.net/123456789/1852 |
| ISSN: | 1027-3719 |
| Appears in Collections: | Research Articles (IDI)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| colebunders-kambugu-idi-res.pdf | | 89Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
