|
|
Makerere University Research Repository >
College of Health Sciences >
School of Health Sciences >
Research Articles (Health-Sciences) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1845
|
| Title: | The Safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda |
| Authors: | Kigozi, Godfrey
H. Gray, Ronald
Wawer, Maria J.
Serwadda, David
Makumbi, Frederick
Watya, Stephen
Nalugoda, Fred
Kiwanuka, Noah
Moulton, Lawrence H.
Chen, Michael Z.
Sewankambo, Nelson K.
Wabwire-Mangen, Fred
Bacon, Melanie C.
Ridzon, Renee
Opendi, Pius
Sempijja, Victor
Settuba, Absolom
Buwembo, Denis
Kiggundu, Valerian
Anyokorit, Margaret
Nkale, James
Kighoma, Nehemia
Charvat, Blake |
| Keywords: | Male circumcision
HIV-positive persons
Sexually transmitted diseases
Circumcision wound |
| Issue Date: | 3-Jun-2008 |
| Publisher: | Public Library of Science |
| Citation: | Kigozi, G. et al (2008). The Safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda. Plos Medicine, 5(6):0911-0918 |
| Abstract: | Background:
The objective of the study was to compare rates of adverse events (AEs) related to male
circumcision (MC) in HIV-positive and HIV-negative men in order to provide guidance for MC
programs that may provide services to HIV-infected and uninfected men.
Methods and Findings:
A total of 2,326 HIV-negative and 420 HIV-positive men (World Health Organization [WHO]
stage I or II and CD4 counts . 350 cells/mm3) were circumcised in two separate but
procedurally identical trials of MC for HIV and/or sexually transmitted infection prevention in
rural Rakai, Uganda. Participants were followed at 1–2 d and 5–9 d, and at 4–6 wk, to assess
surgery-related AEs, wound healing, and resumption of intercourse. AE risks and wound healing
were compared in HIV-positive and HIV-negative men. Adjusted odds ratios (AdjORs) were
estimated by multiple logistic regression, adjusting for baseline characteristics and postoperative
resumption of sex. At enrollment, HIV-positive men were older, more likely to be
married, reported more sexual partners, less condom use, and higher rates of sexually
transmitted disease symptoms than HIV-negative men. Risks of moderate or severe AEs were
3.1/100 and 3.5/100 in HIV-positive and HIV-negative participants, respectively (AdjOR 0.91,
95% confidence interval [CI] 0.47–1.74). Infections were the most common AEs (2.6/100 in HIVpositive
versus 3.0/100 in HIV-negative men). Risks of other complications were similar in the
two groups. The proportion with completed healing by 6 wk postsurgery was 92.7% in HIVpositive
men and 95.8% in HIV-negative men (p¼0.007). AEs were more common in men who
resumed intercourse before wound healing compared to those who waited (AdjOR 1.56, 95% CI
1.05–2.33).
Conclusions:
Overall, the safety of MC was comparable in asymptomatic HIV-positive and HIV-negative
men, although healing was somewhat slower among the HIV infected. All men should be
strongly counseled to refrain from intercourse until full wound healing is achieved. |
| URI: | http://dx.doi.org/10.1371/journal.pmed.0050116
http://hdl.handle.net/123456789/1845 |
| Appears in Collections: | Research Articles (Health-Sciences)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| Kigozi-chs-res.pdf | | 114Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
