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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1839
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| Title: | Pattern of neuropsychological performance among HIV positive patients in Uganda |
| Authors: | Robertson, Kevin R
Nakasujja, Noeline
Wong, Matthew
Musisi, Seggane
Katabira, Elly
Parsons, Thomas D
Ronald, Allan
Sacktor, Ned |
| Keywords: | Neuropsychological
HIV positive
Uganda
HIV/AIDS
Sub-Saharan Africa |
| Issue Date: | 2007 |
| Publisher: | BioMed Central |
| Citation: | Robertson, K. Nakasujja, N., Wong, M., Musisi, S., Katabira, E., Parsons, T.D., Ronald, A., Sactor, N. (2007). Pattern of neuropsychological performance among HIV positive patients in Uganda. BMC Neurology, 7(8) |
| Abstract: | Background: Few studies have examined cognitive functioning of HIV positive patients in sub-Saharan Africa. It cannot be assumed that HIV positive patients in Africa exhibit the same declines
as patients in high-resource settings, since there are differences that may influence cognitive
functioning including nutrition, history of concomitant disease, and varying HIV strains, among
other possibilities. Part of the difficulty of specifying abnormalities in neuropsychological functioning among African HIV positive patients is that there are no readily available African normative
databases. The purpose of the current study was to evaluate the pattern of neuropsychological performance in a sample of HIV positive patients in comparison to HIV negative control subjects
in Uganda. Methods: The neuropsychological test scores of 110 HIV positive patients (WHO Stage 2, n = 21;
WHO Stage 3, n = 69; WHO Stage 4, n = 20) were contrasted with those of 100 control subjects on measures of attention/concentration, mental flexibility, learning/memory, and motor
functioning.
Results: Analysis of covariance (ANCOVA) revealed significant group differences on measures of verbal learning and memory, speed of processing, attention and executive functioning between HIV
seropositive and seronegative subjects.
Conclusion: Ugandan patients with HIV demonstrated relative deficits on measures of verbal learning and memory, speed of processing, attention, and executive functioning compared to HIV
negative controls. These results from a resource limited region where clades A and D are prevalentare consistent with previous findings in the developed world where clade B predominates. |
| URI: | http://www.biomedcentral.com/1471-2377/7/8
doi:10.1186/1471-2377-7-8
http://hdl.handle.net/123456789/1839 |
| ISSN: | 1471-2377 |
| Appears in Collections: | Research Articles (IDI)
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