|
|
Makerere University Research Repository >
College of Health Sciences >
Infectious Diseases Institute >
Research Articles (IDI) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1836
|
| Title: | Clinical presentation and aetiologies of acute or complicated headache among HIV-seropositive patients in a Ugandan clinic |
| Authors: | Katwere, Michael
Kambugu, Andrew
Piloya, Theresa
Wong, Matthew
Hendel-Paterson, Brett
Sande, Merle A
Ronald, Allan
Katabira, Elly
Were, Edward M
Menten, Joris
Colebunders, Robert |
| Keywords: | HIV-seropositive
Clinical
Antiretroviral therapy (ART)
HIV/AIDS |
| Issue Date: | 2009 |
| Publisher: | BioMed Central |
| Citation: | Katwere, M., Kambugu, A., Piloya, T., Wong, M., Hendel-Paterson, B., Sande, M.A., Ronald, A., Katabira, E., Were, E.M., Menten, J., Colebunders, R. (2009). Clinical presentation and aetiologies of acute or complicated headache among HIV-seropositive patients in a Ugandan clinic. Journal of the International AIDS Society, 12(21) |
| Abstract: | Background: We set out to define the relative prevalence and common presentations of the various aetiologies of headache within an ambulant HIV-seropositive adult population in Kampala,
Uganda.
Methods: We conducted a prospective study of adult HIV-1-seropositive ambulatory patients
consecutively presenting with new onset headaches. Patients were classified as focal-febrile, focalafebrile, non-focal-febrile or non-focal-afebrile, depending on presence or absence of fever and
localizing neurological signs. Further management followed along a pre-defined diagnostic algorithm to an endpoint of a diagnosis. We assessed outcomes during four months of follow up.
Results: One hundred and eighty patients were enrolled (72% women). Most subjects presented
at WHO clinical stages III and IV of HIV disease, with a median Karnofsky performance rating of 70% (IQR 60-80).
The most common diagnoses were cryptococcal meningitis (28%, n = 50) and bacterial sinusitis (31%, n = 56). Less frequent diagnoses included cerebral toxoplasmosis (4%, n = 7), and
tuberculous meningitis (4%, n = 7). Thirty-two (18%) had other diagnoses (malaria, bacteraemia,etc.). No aetiology could be elucidated in 28 persons (15%). Overall mortality was 13.3% (24 of
180) after four months of follow up. Those without an established headache aetiology had good clinical outcomes, with only one death (4% mortality), and 86% were ambulatory at four months.
Conclusion: In an African HIV-infected ambulatory population presenting with new onsetheadache, aetiology was found in at least 70%. Cryptococcal meningitis and sinusitis accounted for more than half of the cases. |
| URI: | doi:10.1186/1758-2652-12-21
http://hdl.handle.net/123456789/1836 |
| ISSN: | 1758-2652
http://www.jiasociety.org/content/12/1/21 |
| Appears in Collections: | Research Articles (IDI)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| katwere-idi-res.pdf | | 234Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
