|
Makerere University Research Repository >
College of Health Sciences >
Infectious Diseases Institute >
Research Articles (IDI) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1810
|
| Title: | Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria |
| Authors: | Byakika-Kibwika, Pauline
Lamorde, Mohammed
Mayanja-Kizza, Harriet
Merry, Concepta
Colebunders, Bob
Van Geertruyden, Jean-Pierre |
| Keywords: | Artemether–lumefantrine
Safety
Malaria
Effectiveness
Efficacy
Antimalarial therapy
Falciparum malaria
Antiretroviral therapy
CD4 counts
HIV/AIDS |
| Issue Date: | 2009 |
| Publisher: | Dove Medical Press |
| Citation: | Byakika-Kibwika P., Lamorde, M., Mayanja-Kizza, H., Merry, C., Colebunders, B., Van Geertruyden, J.P. (2009). Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria. Therapeutics and Clinical Risk Management, 5 |
| Abstract: | Artemether–lumefantrine is one of the artemisisnin-based combination therapies
recommended for treatment of uncomplicated falciparum malaria. The drug combination is
highly efficacious against sensitive and multidrug resistant falciparum malaria. It offers the
advantage of rapid clearance of parasites by artemether and the slower elimination of residual
parasites by lumefantrine. The combination can be used in all populations except pregnant mothers in the first trimester where safety is still uncertain. There are still concerns about safety and pharmacokinetics of the drug combination in children, especially infants, pregnant mothers and drug interactions with mainly non-nucleoside reverse transcriptase inhibitors and protease inhibitors used for HIV therapy. |
| URI: | http://hdl.handle.net/123456789/1810 |
| ISSN: | 1176-6336 |
| Appears in Collections: | Research Articles (IDI)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| byakika-idi-res.pdf | | 235Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
