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| Title: | Kidney function and DDT value comparison in pre- and post-spray plasma of the spray personnel in Northern Uganda in 2008 |
| Authors: | Bimenya, G. S
Habarulema, M.
Okot, J.P.
Okwi, A.L.
Lugemwa, Myers |
| Keywords: | Malaria
Mosquito
Control
Insecticides
Urea
Creatinine
In-door residual spray
Dichlorodiphenyltrichloroethane (DDT)
Northern Uganda
Kidney function |
| Issue Date: | Oct-2009 |
| Publisher: | International Formulae Group |
| Citation: | bimenya, G.S., Habarulema, M., Okot, J.P., Okwi, A.L., Lugemwa, M. (2009). Kidney function and DDT value comparison in pre- and post-spray plasma of the spray personnel in Northern Uganda in 2008. International Journal of biological and Chemical Sciences, 3(5) |
| Abstract: | In-door residual spray of the insecticide dichlorodiphenyltrichloroethane was re-introduced for
malaria control in Uganda and there was need to assess its health impact among the spray personnel. To
compare kidney function and the insecticide values in pre-and post-spray plasma of spray persons in northern
Uganda, heparinized blood samples were analyzed in the Department of Pathology, College of Health
Sciences, Makerere University, for the insecticide and its main metabolite dichlorodiphenylethane using
enzyme linked immunosorbent assay kits from AbraxisTM (USA). Urea and creatinine were analyzed on
KonelabTM (Finland) chemistry analyzer. The 109 pre-spray samples had mean (SD) values of the
insecticide/metabolite of 63 (19) while the 96 post-spray samples had mean (SD) of 77 (26) ppb. The 96 prespray
samples had urea concentration mean (SD) of 3.50 (1.11) mmol/L while 119 post-spray samples had
mean (SD) of 3.86 (1.07) mmol/L. The pre-spray samples had creatinine mean (SD) of 65.58 (12.05) μmol/L
whereas the post-spray had mean (SD) of 79.82 (14.81) μmol/L. The post-spray urea and creatinine values
were higher than the pre-spray (p<0.05) despite the fact that all were within reference ranges. The insecticide
had no deleterious effects on kidney function. Therefore, dichlorodiphenyltrichloroethane can be used safely
for in-door residual spray in control of malaria disease. |
| URI: | http://ajol.info/index.php/ijbcs
http://hdl.handle.net/123456789/1799 |
| ISSN: | 1991-8631 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| bimenya-chs-res.pdf | | 164Kb | Adobe PDF | View/Open |
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