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|Title: ||The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda|
|Authors: ||Ocama, Ponsiano|
Opio, Kenneth C.
|Keywords: ||Liver disease|
|Issue Date: ||2008 |
|Publisher: ||Makerere University Medical School|
|Citation: ||Ocama, P., Katwere, M., Piloya, T., Feld, J., Opio, K.C., Katabira, E., Thomas, D., Colebunders, R., Ronald, A. (2008). The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda. African Health Sciences, 8(1)|
|Abstract: ||Background: Liver diseases are common in patients with HIV due to viral hepatitis B and C co-infections, opportunistic infections or
malignancies, antiretroviral drugs and drugs for opportunistic infections.
Objective: To describe the spectrum of liver diseases in HIV-infected patients attending an HIV clinic in Kampala, Uganda.
Method: Consecutive patients presenting with jaundice, right upper quadrant pain with fever or malaise, ascites and/or tender
hepatomegaly were recruited and underwent investigations to evaluate the cause of their liver disease.
Results: Seventy-seven consecutive patients were recruited over an eleven month period. Of these, 23 (30%) had increased transaminases
because of nevirapine (NVP) and/or isoniazid (INH) hepatotoxicity. Although 14 (61%) patients with drug-induced liver disease
presented with jaundice, all recovered with drug discontinuation. Hepatitis B surface antigen was positive in 11 (15%) patients while
anti-hepatitis C antibody was reactive in only 2 (3%). Probable granulomatous hepatitis due to tuberculosis was diagnosed in 7 (9%)
patients and all responded to anti-TB therapy. Other diagnoses included alcoholic liver disease, AIDS cholangiopathy, hepatocellular
carcinoma, schistosomiasis, haemangioma and hepatic adenoma. Twelve (16%) patients died during follow-up of which 7 (9%) died
because of liver disease.
Conclusion: Drug history, liver enzyme studies, ultrasound, and hepatitis B and C investigations identified the probable etiology in 60
(78%) of 77 patients with HIV infection presenting with symptoms and/or signs of liver disease.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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