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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1752
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| Title: | The effects of male circumcision on female partner's genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda |
| Authors: | Kigozi, Godfrey
Gray, Ronald H.
Serwadda, David
Makumbi, Frederick
Nalugoda, Fred
Watya, Stephen
Moulton, Laurence
Chen, Michael Z.
Sewankambo, Nelson K.
Kiwanuka, Noah
Sempijja, Victor
Lutalo, Tom
Kagayii, Joseph
Wabwire-Mangen, Fred
Ridzon, Renee
Bacon, Melanie
Williams, Caroline
Wawer, Maria J. |
| Keywords: | Male circumcision
Female genital symptoms
Vaginal infections
HIV/AIDS
Vaginal discharge
Dysuria |
| Issue Date: | 2009 |
| Publisher: | Elsevier |
| Citation: | Kigozi, G., Gray, R.H., Serwadda, D., Makumbi, F., Nalugoda, F., Watya, S., Moulton, L., Chen, M.Z., Sewankambo, N.K., Kiwanuka, N., Sempijja, V., Lutalo, T., Kagayii, J., Wabwire-Mangen, F., Ridzon, R., Bacon, M., Williams, C., Wawer, M.J. (2009). The effects of male circumcision on female partner's genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda. American Journal of Obstetrics and Gynecology, 200(1) |
| Abstract: | Objective—To assess effects of male circumcision on female genital symptoms, and vaginal infections.
Methods—HIV-negative men enrolled in a trial were randomized to immediate or delayed
circumcision (control arm). Genital symptoms, BV and trichomonas were assessed in HIV-negative wives of married participants. Adjusted prevalence risk ratios (adjPRR) and 95% confidence intervals (95%CI) were assessed by multivariable log-binomial regression, intent-to-treat analyses.
Results—783 wives of control and 825 wives of intervention arm men were comparable at
enrollment. BV at enrollment was higher in control (38.3%) than intervention arm spouses (30.5%, p=0.001). At one year follow up, intervention arm wives reported lower rates of genital ulceration (adjPRR 0.78, 95%CI 0.63–0.97), but there were no differences in vaginal discharge or dysuria. The risk of trichomonas was reduced in intervention arm wives (adjPRR 0.52, 95%CI 0.05–0.98), as were the risks of any BV (adjPRR 0.60, 95%CI 0.38–0.94) and severe BV (PRR = 0.39, 95%CI 0.24–
0.64).
Conclusions—Male circumcision reduces the risk of ulceration, trichomonas and BV in female partners. |
| URI: | doi:10.1016/j.ajog.2008.07.069.
http://hdl.handle.net/123456789/1752 |
| ISSN: | 0002-9378 |
| Appears in Collections: | Research Articles (Health-Sciences)
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