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|Title: ||The effects of male circumcision on female partner's genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda|
|Authors: ||Kigozi, Godfrey|
Gray, Ronald H.
Chen, Michael Z.
Sewankambo, Nelson K.
Wawer, Maria J.
|Keywords: ||Male circumcision|
Female genital symptoms
|Issue Date: ||2009 |
|Citation: ||Kigozi, G., Gray, R.H., Serwadda, D., Makumbi, F., Nalugoda, F., Watya, S., Moulton, L., Chen, M.Z., Sewankambo, N.K., Kiwanuka, N., Sempijja, V., Lutalo, T., Kagayii, J., Wabwire-Mangen, F., Ridzon, R., Bacon, M., Williams, C., Wawer, M.J. (2009). The effects of male circumcision on female partner's genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda. American Journal of Obstetrics and Gynecology, 200(1)|
|Abstract: ||Objective—To assess effects of male circumcision on female genital symptoms, and vaginal infections.
Methods—HIV-negative men enrolled in a trial were randomized to immediate or delayed
circumcision (control arm). Genital symptoms, BV and trichomonas were assessed in HIV-negative wives of married participants. Adjusted prevalence risk ratios (adjPRR) and 95% confidence intervals (95%CI) were assessed by multivariable log-binomial regression, intent-to-treat analyses.
Results—783 wives of control and 825 wives of intervention arm men were comparable at
enrollment. BV at enrollment was higher in control (38.3%) than intervention arm spouses (30.5%, p=0.001). At one year follow up, intervention arm wives reported lower rates of genital ulceration (adjPRR 0.78, 95%CI 0.63–0.97), but there were no differences in vaginal discharge or dysuria. The risk of trichomonas was reduced in intervention arm wives (adjPRR 0.52, 95%CI 0.05–0.98), as were the risks of any BV (adjPRR 0.60, 95%CI 0.38–0.94) and severe BV (PRR = 0.39, 95%CI 0.24–
Conclusions—Male circumcision reduces the risk of ulceration, trichomonas and BV in female partners.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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