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|Title: ||Geographic HIV Type 1 Subtype distribution in Rakai District, Uganda.|
|Authors: ||Sewankambo, Nelson K.|
Collinson-Streng, Aleisha N.
Redd, Andrew D.
Lamers, Susanna L.
Gray, Ronald H.
Wawer, Maria J.
Quinn, Thomas C.
HIV Type 1 Subtype
|Issue Date: ||2009 |
|Publisher: ||Mary Ann Liebert|
|Citation: ||Sewankambo, N.K., Collinson-Streng, A.N., Redd, A.D., Serwadda, D., Rezapour, M., Lamers, S.L., Gray, R.H., Wawer, M.J., Quinn, T.C., Laeyendecker, O. (2009). Geographic HIV Type 1 Subtype distribution in Rakai District, Uganda. Aids Research and Human Retroviruses, 25(10)|
|Abstract: ||To analyze HIV-1 subtype distribution, sequence analysis was performed on serum specimens obtained in 1994 from the Rakai Health Sciences community cohort in Uganda. Portions of gag-p24 and env-gp41 were sequenced and HIV subtype was determined for 773 subjects residing in 10 community clusters in rural Uganda. Subtypes A (17%) and D (70%) were the most common strains
in the population. Subtype distribution varied by geographic region with significantly more subtype A in northern community clusters compared with southern clusters (21% vs. 8%, p < 0.001) and more
subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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