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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1747
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| Title: | Geographic HIV Type 1 Subtype distribution in Rakai District, Uganda. |
| Authors: | Sewankambo, Nelson K.
Collinson-Streng, Aleisha N.
Redd, Andrew D.
Serwadda, David
Rezapour, Mona
Lamers, Susanna L.
Gray, Ronald H.
Wawer, Maria J.
Quinn, Thomas C.
Laeyendecker, Oliver |
| Keywords: | HIV/AIDS
Rakai District
Uganda
Rural areas
HIV Type 1 Subtype |
| Issue Date: | 2009 |
| Publisher: | Mary Ann Liebert |
| Citation: | Sewankambo, N.K., Collinson-Streng, A.N., Redd, A.D., Serwadda, D., Rezapour, M., Lamers, S.L., Gray, R.H., Wawer, M.J., Quinn, T.C., Laeyendecker, O. (2009). Geographic HIV Type 1 Subtype distribution in Rakai District, Uganda. Aids Research and Human Retroviruses, 25(10) |
| Abstract: | To analyze HIV-1 subtype distribution, sequence analysis was performed on serum specimens obtained in 1994 from the Rakai Health Sciences community cohort in Uganda. Portions of gag-p24 and env-gp41 were sequenced and HIV subtype was determined for 773 subjects residing in 10 community clusters in rural Uganda. Subtypes A (17%) and D (70%) were the most common strains
in the population. Subtype distribution varied by geographic region with significantly more subtype A in northern community clusters compared with southern clusters (21% vs. 8%, p < 0.001) and more
subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design. |
| URI: | doi:10.1089/aid.2009.0127.
http://hdl.handle.net/123456789/1747 |
| ISSN: | 0889-2229 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| sewankambo-chs-res.pdf | | 888Kb | Adobe PDF | View/Open |
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