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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1740
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| Title: | Hepatotoxicity during nevirapine-based fixed-dose combination antiretroviral therapy in Kampala, Uganda. |
| Authors: | Hahn, Judith A.
Maier, Marissa
Byakika-Tusiime, Jayne
Oyugi, Jessica H.
Bangsberg, David R. |
| Keywords: | HIV/AIDS
Uganda
Antiretroviral therapy (ART)
Hepatotoxicity |
| Issue Date: | 2007 |
| Publisher: | Sage Publications |
| Citation: | Hahn, J.A, Maier, M., Byakika-Tusiime, J., Oyugi, J.H., Bangsberg, D.R. (2007). Hepatotoxicity during nevirapine-based fixed-dose combination antiretroviral therapy in Kampala, Uganda. Journal- International Association of Physicians in Aids Care, 6(2) |
| Abstract: | Background: Generic, low-cost, nevirapine (NVP)-based antiretroviral therapy (ART) has improved survival in HIV infected individuals living in resource-limited settings.
However, there is concern about the potential hepatotoxicity of these regimens.
Methods: The authors conducted a prospective study of persons initiating self-pay Triomune or Maxivir therapy in Kampala, Uganda.
Results: The 97 study participants were predominantly women (64%), median age was 35 (interquartile range [IQR] 30-40), median CD4 at baseline was 56 cells/mm3 (IQR 8-138), and 19% had lifetime alcohol problems (CAGE ≥ 2). Severe liver enzyme elevations (LEEs) of grade 3-4 were rare (2.2%); however, 1 patient died in the setting of grade 4 LEEs. Grade 1-4 LEEs occurred among 22.2% of participants, and 9.8% had new grade 1-4 LEEs after the initiation of treatment.
Discussion: The authors found that LEEs were common but that severe hepatotoxicity in persons initiating NVP-based ART was infrequent yet potentially life-threatening. Monitoring for NVP-related severe hepatic toxicity should be part of expanding antiretroviral treatment programs in resourcelimited settings. |
| URI: | DOI: 10.1177/1545109707299356
http://hdl.handle.net/123456789/1740 |
| ISSN: | 1081-454X |
| Appears in Collections: | Research Articles (Health-Sciences)
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| byakika-hahn-chs-res.pdf | | 85Kb | Adobe PDF | View/Open |
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