Makerere University Research Repository >
College of Health Sciences >
School of Health Sciences >
Research Articles (Health-Sciences) >
Please use this identifier to cite or link to this item:
|Title: ||Hepatotoxicity during nevirapine-based fixed-dose combination antiretroviral therapy in Kampala, Uganda.|
|Authors: ||Hahn, Judith A.|
Oyugi, Jessica H.
Bangsberg, David R.
Antiretroviral therapy (ART)
|Issue Date: ||2007 |
|Publisher: ||Sage Publications|
|Citation: ||Hahn, J.A, Maier, M., Byakika-Tusiime, J., Oyugi, J.H., Bangsberg, D.R. (2007). Hepatotoxicity during nevirapine-based fixed-dose combination antiretroviral therapy in Kampala, Uganda. Journal- International Association of Physicians in Aids Care, 6(2)|
|Abstract: ||Background: Generic, low-cost, nevirapine (NVP)-based antiretroviral therapy (ART) has improved survival in HIV infected individuals living in resource-limited settings.
However, there is concern about the potential hepatotoxicity of these regimens.
Methods: The authors conducted a prospective study of persons initiating self-pay Triomune or Maxivir therapy in Kampala, Uganda.
Results: The 97 study participants were predominantly women (64%), median age was 35 (interquartile range [IQR] 30-40), median CD4 at baseline was 56 cells/mm3 (IQR 8-138), and 19% had lifetime alcohol problems (CAGE ≥ 2). Severe liver enzyme elevations (LEEs) of grade 3-4 were rare (2.2%); however, 1 patient died in the setting of grade 4 LEEs. Grade 1-4 LEEs occurred among 22.2% of participants, and 9.8% had new grade 1-4 LEEs after the initiation of treatment.
Discussion: The authors found that LEEs were common but that severe hepatotoxicity in persons initiating NVP-based ART was infrequent yet potentially life-threatening. Monitoring for NVP-related severe hepatic toxicity should be part of expanding antiretroviral treatment programs in resourcelimited settings.|
|URI: ||DOI: 10.1177/1545109707299356|
|Appears in Collections:||Research Articles (Health-Sciences)|
Files in This Item:
All items in DSpace are protected by copyright, with all rights reserved.