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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1698
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| Title: | Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. |
| Authors: | Stein, Catherine M.
Guwatudde, David
Nakakeeto, Margaret
Pierre, Peters
Elston, Robert C.
Tiwari, Hemant K.
Mugerwa, Roy
Whalen, Christopher C. |
| Keywords: | Heritability Analysis
Cytokines
Tuberculosis
Genetic Susceptibility
TB
Uganda
Lung diseases |
| Issue Date: | 9-May-2003 |
| Publisher: | University of Chicago Press |
| Citation: | Stein, C.M., Guwatudde, D., Nakakeeto, M., Pierre, P., Elston, R.C., Tiwari, H.K., Mugerwa, R., Whalen, C.C. (2003). Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. Journal of Infectious Diseases, 187 |
| Abstract: | Numerous studies have provided support for genetic susceptibility to tuberculosis (TB); however, heterogeneity in disease expression has hampered previous genetic studies. The purpose of this work was to investigate possible intermediate phenotypes for TB. A set of cytokine profiles, including antigen-stimulated whole-blood assays for interferon (IFN)–γ, tumor necrosis factor (TNF)–α, transforming growth factor (TGF)–β, and the ratio of IFN to TNF, were analyzed in 177 pedigrees from a community in Uganda with a high prevalence of TB. The heritability of these variables was estimated after adjustment for covariates, and TNF-α, in particular, had an estimated heritability of 68%. A principal component analysis of IFN-γ, TNF-α, and TGF-β reflected the immunologic model of TB. In this analysis, the first component explained >38% of the variation in the data. This analysis illustrates the value of such intermediate phenotypes in mapping susceptibility loci for TB and demonstrates that this area deserves further research. |
| URI: | http://hdl.handle.net/123456789/1698 |
| ISSN: | 0022-1899 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| Guwatudde-Chs-Res.pdf | | 113Kb | Adobe PDF | View/Open |
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