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|Title: ||Heritability analysis of cytokines as intermediate phenotypes of tuberculosis.|
|Authors: ||Stein, Catherine M.|
Elston, Robert C.
Tiwari, Hemant K.
Whalen, Christopher C.
|Keywords: ||Heritability Analysis|
|Issue Date: ||9-May-2003 |
|Publisher: ||University of Chicago Press|
|Citation: ||Stein, C.M., Guwatudde, D., Nakakeeto, M., Pierre, P., Elston, R.C., Tiwari, H.K., Mugerwa, R., Whalen, C.C. (2003). Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. Journal of Infectious Diseases, 187|
|Abstract: ||Numerous studies have provided support for genetic susceptibility to tuberculosis (TB); however, heterogeneity in disease expression has hampered previous genetic studies. The purpose of this work was to investigate possible intermediate phenotypes for TB. A set of cytokine profiles, including antigen-stimulated whole-blood assays for interferon (IFN)–γ, tumor necrosis factor (TNF)–α, transforming growth factor (TGF)–β, and the ratio of IFN to TNF, were analyzed in 177 pedigrees from a community in Uganda with a high prevalence of TB. The heritability of these variables was estimated after adjustment for covariates, and TNF-α, in particular, had an estimated heritability of 68%. A principal component analysis of IFN-γ, TNF-α, and TGF-β reflected the immunologic model of TB. In this analysis, the first component explained >38% of the variation in the data. This analysis illustrates the value of such intermediate phenotypes in mapping susceptibility loci for TB and demonstrates that this area deserves further research.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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