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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1688
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| Title: | Human Papillomavirus type distribution in invasive cervical cancer in Uganda |
| Authors: | Odida, Michael
de Sanjosé, Silvia
Quint, Wim
Bosch, Xavier F
Klaustermeier, Joellen
Weiderpass, Elisabete |
| Keywords: | Epidemiological studies
Human papillomaviruses (HPV)
Cervical cancer
Cancer
HPV immunization
Cervical carcinoma
Uganda |
| Issue Date: | 24-Jun-2008 |
| Publisher: | BioMed Central |
| Citation: | Odida, M., de Sanjosé, S., Quint, W., Bosch, X.F., Klaustermeier, J., Weiderpass, E. (2008). Human papillomavirus type distribution in invasive cervical cancer in Uganda. BMC Infectious Diseases, 8(85) |
| Abstract: | Background: We conducted a study aiming to describe Human Papillomavirus (HPV) type distribution in invasive cervical carcinoma in Uganda.
Methods: 191 archival cervical carcinoma samples diagnosed in the Department of Pathology, Makerere University in Kampala between 1968 and 1992 were analysed using a sensitive PCRReverse Hybridization Line Probe Assay.
Results: Out of the 186 cases of confirmed invasive cervical cancer in the study paraffin blocks, 114 were positive for HPV DNA. Specific HPV genotypes were identifiable in 109 cases: HPV 16, 18, 31, 35, 39, 44, 45, 51, 52 and 70. These occurred as single infections in 105 cases (96.3%) and as multiple infections in 4 cases (3.7%). HPV 16 or 18 accounted for 80% (84/105) of cases with single infection.
Conclusion: The results of this study confirm the role of HPV 16 and 18 in cervical cancer pathogenesis in the Ugandan population. The results suggest that the currently available HPV vaccines against HPV 16 and 18 could possibly prevent the majority of invasive cervical cancers in Uganda. |
| Description: | The study is part of the international study RIS HPV TT coordinated at ICO, Barcelona, Spain.
The work reported in this paper was undertaken during the tenure of an Expertise Transfer Fellowship awarded by the International Agency for Research on Cancer to Dr. Weiderpass and Prof. Lambert. |
| URI: | http://www.biomedcentral.com/1471-2334/8/85
http://hdl.handle.net/123456789/1688 |
| ISSN: | 1471-2334 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| odida-silvia-chs-res.pdf | | 260Kb | Adobe PDF | View/Open |
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