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|Title: ||The international HIV dementia scale: a new rapid screening test for HIV dementia.|
|Authors: ||Sacktor, Ned C.|
Skolasky, Richard L.
Selnes, Ola A.
McArthur, Justin C.
Katabira, Elly T.
|Issue Date: ||2005 |
|Publisher: ||Lippincott Williams & Wilkins|
|Citation: ||Sacktor, N.C., Wong, M., Nakasujja, N., Skolasky, R.L., Selnes, O.A., Musisi, S., Robertson, K., McArthur, J.C., Ronald, A., Katabira, E.T. (2005). The international HIV dementia scale: a new rapid screening test for HIV dementia. AIDS, 19|
|Abstract: ||Objective: HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is critical for diagnosing this condition. The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda.
Design: Two cross-sectional cohort studies designed to evaluate for the presence of HIV dementia.
Methods: Sixty-six HIV-positive individuals in the US and 81 HIV-positive individuals in Uganda received the IHDS and full standardized neurological and neuropsychological assessments. The sensitivity and specificity of varying cut-off scores of the IHDS were evaluated in the two cohorts.
Results: In the US cohort, the mean IHDS score for HIV-positive individuals without dementia and with dementia were 10.6 and 9.3 respectively (P < 0.001). Using the cutoff of ≤ 10, the sensitivity and specificity for HIV dementia with the IHDS were 80% and 57% respectively in the US cohort, and 80% and 55% respectively in the Uganda cohort.
Conclusions: The IHDS may be a useful screening test to identify individuals at risk for HIV dementia in both the industrialized world and the developing world. Full neuropsychological testing should then be performed to confirm a diagnosis of HIV dementia.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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