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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1658
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| Title: | Why bacteria derived R-M nucleic enzymatic peptides are likely efficient therapeutic molecules for use in the design and development of novel HIV inhibitory strategies |
| Authors: | Wayengera, Misaki |
| Keywords: | Restriction modification (R-M) systems
Restriction enzymes (REases/RNases)
Methyltranferases (MTases)
Human immunodeficiency virus (HIV)
Immune reconstitution
Probiotic microbicides |
| Issue Date: | 17-Jun-2008 |
| Publisher: | Academic Journals |
| Citation: | Wayengera, M. (2008). Why bacteria derived R-M nucleic enzymatic peptides are likely efficient therapeutic molecules for use in the design and development of novel HIV inhibitory strategies. African Journal of Biotechnology, 7 (12): 1791-1796 |
| Series/Report no.: | African Journal of Biotechnology
7 (12) |
| Abstract: | In the past, we have identified, described and isolated over 200 bacteria derived Restriction
Modification (R-M) nucleic enzymatic peptides as efficient therapeutic molecules for use in the
development of novel HIV inhibitory strategies. In the issuing months of our publications, 3 questions
have been directed to our work; (1) HIV is an RNA virus, thus restriction peptides are impotent as
defense peptides. (2) HIV genome is encapsulated in nuclear capsid and viral envelope, making access
impossible. (3) Human genome contains several palindromes recognizable by R-M peptides, making
safety delineation critical. This paper serves to provide succinct responses to these issues, and
highlight critical strategies being employed in ensuring the development of safe Microbides and
therapeutic vaccines based on this approach. |
| URI: | http://www.academicjournals.org/AJB
http://hdl.handle.net/123456789/1658 |
| ISSN: | 1684–5315 |
| Appears in Collections: | Research Articles (Bio-Medical)
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Files in This Item:
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Description |
Size | Format |
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| wayengera-misaki-chs-res4.pdf | | 281Kb | Adobe PDF | View/Open |
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