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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1654
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| Title: | PREX-1979: modeling the first ever prototype of a new generation of microbicides for preventing HIV infection among high risk women |
| Authors: | Wayengera, Misaki |
| Keywords: | HIV/AIDS
Novel Microbicides Strategies
Restriction Modification Systems
HIV genomes
Combination-Microbicides |
| Issue Date: | 16-May-2007 |
| Publisher: | Academic Journals |
| Citation: | Wayengera, M. (2007). PREX-1979: modeling the first ever prototype of a new generation of microbicides for preventing HIV infection among high risk women. African Journal of Biotechnology, 6(10):1221-1224 |
| Series/Report no.: | African Journal of Biotechnology
6(10) |
| Abstract: | Impregnating a proteolytic substrate of specifity to viral envelope with a restriction enzyme cleaving the
HIV genome could generate a novel line of microbicide. Web Cutter version 2.0 aimed at identifying
which enzyme can cleave HIV-1 and 2 genomes in 10 or > cuts was employed. Computational analysis
indicate that of 291, 17 (5.8%) enzymes had 10 or more cuts in the HIV- 1/SIVcpz genome as compared
to 25 (8.9%) for HIV-2/SIVsmm with 6 enzymes (Eco-130I, EcoT141, ApoI, AcsI, BssTII, and StyI) having a
mutual ability to cleave HIV-1 and 2 in 10 and more cuts. Although not a proteolytic enzyme, the
surfactant Savvy/C31G (Cellegy) was identified as a safe and close candidate for our proteolytic
substrate. With biochemical compound modeling, it is possible to stably impregnate the center of
surfactant/detergent molecule with a natural product. The PREX Model may be explored to develop
novel lines of microbicides aimed at preventing HIV and other viral STI transmission in humans. |
| URI: | http://www.academicjournals.org/AJB
http://hdl.handle.net/123456789/1654 |
| ISSN: | 1684–5315 |
| Appears in Collections: | Research Articles (Bio-Medical)
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Files in This Item:
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Size | Format |
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| wayengera-misaki-chs-res.pdf | | 68Kb | Adobe PDF | View/Open |
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